ArticleAJNR. American journal of neuroradiology2018
CT Attenuation Analysis of Carotid Intraplaque Hemorrhage.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Embolic Stroke of Undetermined Source and Carotid Intraplaque Hemorrhage on MRI : A Systemic Review and Meta-Analysis.Clinical neuroradiology · 2021Pooled it
- Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of Neuroradiology.AJNR. American journal of neuroradiology · 2018Guideline
- Agreement across different measurements for internal carotid artery stenosis in patients with TIA or stroke in the CONVINCE trial.European radiology · 2026Trial
- Intracranial Arterial Calcification and Its Impact on Subsequent Ischemic Cerebral Events: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Role of T1-weighted MRI in Identifying Coronary Intraplaque Hemorrhage: CATCH the Truly High-Risk Plaque.Journal of atherosclerosis and thrombosis · 2026Review
- Thrombus composition identifies distinct etiologic phenotypes in embolic stroke of undetermined source.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Improving Risk Stratification for Transient Ischaemic Attacks and Ischaemic Stroke in Patients with Coronary Artery Disease: A Combined Radiomics Analysis of Multimodal Adipose Tissue.Diagnostics (Basel, Switzerland) · 2026Article
- Carotid plaque characteristics by computed Tomography: A diagnostic accuracy systematic review.International journal of cardiology. Heart & vasculature · 2025Review
- Assessment of Attenuation in Pericarotid Fat among Patients with Carotid Plaque and Spontaneous Carotid Dissection.AJNR. American journal of neuroradiology · 2025Article
- The biological applications of near-infrared optical nanomaterials in atherosclerosis.Journal of nanobiotechnology · 2024Review
- Machine Learning Detects Symptomatic Plaques in Patients With Carotid Atherosclerosis on CT Angiography.Circulation. Cardiovascular imaging · 2024Article
- The Prepetrous Segment of the Internal Carotid Artery as a Neglected Site of Symptomatic Atherosclerosis: A Single-Center Series.Journal of clinical medicine · 2024Article
- Evaluation of the Correlation Between Distribution Location and Vulnerability of Carotid Plaque in Patients with Transient Ischemic Attack.Vascular health and risk management · 2024Article
- Quantification of Low-Attenuation Plaque Burden from Coronary CT Angiography: A Head-to-Head Comparison with Near-Infrared Spectroscopy Intravascular US.Radiology. Cardiothoracic imaging · 2023Article
- Significance of Intra-plaque Hemorrhage for the Development of High-Risk Vulnerable Plaque: Current Understanding from Basic to Clinical Points of View.International journal of molecular sciences · 2023Review
- Novel Imaging-Based Biomarkers for Identifying Carotid Plaque Vulnerability.Biomolecules · 2023Review
- Identification of vulnerable carotid plaque with histologically validated CT-derived plaque maps.The British journal of radiology · 2023Article
- Analysis of carotid vulnerable plaque MRI high-risk features and clinical risk factors associated with concomitant acute cerebral infarction.BMC cardiovascular disorders · 2023Article
- Imaging the Vulnerable Carotid Plaque with CT: Caveats to Consider. Comment on Wang et al. Identification Markers of Carotid Vulnerable Plaques: An Update.Biomolecules · 2023Article
- Carotid Plaque Vulnerability Diagnosis by CTA versus MRA: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIntraplaque hemorrhage is considered a leading parameter of carotid plaque vulnerability. Our purpose was to assess the CT characteristics of intraplaque hemorrhage with histopathologic correlation to identify features that allow for confirming or ruling out the intraplaque hemorrhage. MATERIALS AND
methodsThis retrospective study included 91 patients (67 men; median age, 65 ± 7 years; age range, 41-83 years) who underwent CT angiography and carotid endarterectomy from March 2010 to May 2013. Histopathologic analysis was performed for the tissue characterization and identification of intraplaque hemorrhage. Two observers assessed the plaque's attenuation values by using an ROI (≥ 1 and ≤2 mm
resultsA total of 169 slices were assessed (59 intraplaque hemorrhage, 63 lipid-rich necrotic core, and 47 fibrous); the average values of the intraplaque hemorrhage, lipid-rich necrotic core, and fibrous tissue were 17.475 Hounsfield units (HU) and 18.407 HU, 39.476 HU and 48.048 HU, and 91.66 HU and 93.128 HU, respectively, before and after the administration of contrast medium. The Mann-Whitney test showed a statistically significant difference of HU values both in basal and after the administration of contrast material phase. Receiver operating characteristic analysis showed a statistical association between intraplaque hemorrhage and low HU values, and a threshold of 25 HU demonstrated the presence of intraplaque hemorrhage with a sensitivity and specificity of 93.22% and 92.73%, respectively. The Wilcoxon test showed that the attenuation of the plaque before and after administration of contrast material is different (intraplaque hemorrhage, lipid-rich necrotic core, and fibrous tissue had
conclusionsThe results of this preliminary study suggest that CT can be used to identify the presence of intraplaque hemorrhage according to the attenuation. A threshold of 25 HU in the volume acquired after the administration of contrast medium is associated with an optimal sensitivity and specificity. Special care should be given to the correct identification of the ROI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.