ReviewInternational journal of molecular sciences2017
Aquaporins during Pregnancy: Their Function and Significance.
Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Parkinson's Spectrum Mechanisms in Pregnancy: Exploring Hypothetical Scenarios for MSA in the Era of ART.International journal of molecular sciences · 2025Review
- Cooperation of aquaporin 5 and the adrenergic system in the initiation of birth in rat model.Heliyon · 2024Article
- Effect of Obesity on Aquaporin5 Expression in Human Placental and Uterus Tissues.Journal of clinical medicine · 2024Article
- Unveiling the human fetal-maternal interface during the first trimester: biophysical knowledge and gaps.Frontiers in cell and developmental biology · 2024Review
- The Role of Fetal Membranes during Gestation, at Term, and Preterm Labor.Placenta and reproductive medicine · 2023Article
- Placental ion channels: potential target of chemical exposure.Biology of reproduction · 2023Review
- A longitudinal epigenome-wide association study of preeclamptic and normotensive pregnancy.Epigenetics communications · 2023Article
- Aquaporins in Reproductive System.Advances in experimental medicine and biology · 2023Review
- Physiological Cooperation between Aquaporin 5 and TRPV4.International journal of molecular sciences · 2022Review
- Functional role and regulation of permeability-glycoprotein (P-gp) in the fetal membrane during drug transportation.American journal of reproductive immunology (New York, N.Y. : 1989) · 2022Article
- The Effect of Citral on Aquaporin 5 and Trpv4 Expressions and Uterine Contraction in Rat-An Alternative Mechanism.Life (Basel, Switzerland) · 2021Article
- Preexisting hypertension and pregnancy-induced hypertension reveal molecular differences in placental proteome in rodents.Physiological genomics · 2021Article
- Article
- Aquaporin 3 promotes human extravillous trophoblast migration and invasion.Reproductive biology and endocrinology : RB&E · 2021Article
- High Levels of Tumor Necrosis Factor-Alpha Reduce Placental Aquaporin 3 Expression and ImpairFrontiers in physiology · 2021Article
- Review
- Aquaporin 1 affects pregnancy outcome and regulates aquaporin 8 and 9 expressions in the placenta.Cell and tissue research · 2020Article
- Pituitary Hormones (FSH, LH, PRL, and GH) Differentially Regulate AQP5 Expression in Porcine Ovarian Follicular Cells.International journal of molecular sciences · 2019Article
- Significance of transient receptor potential vanilloid 4 and aquaporin 5 co-expression in the rat uterus at term.Heliyon · 2019Article
- Uterine GαFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Water is the major component of cells and tissues, and the movement of water across the cell membrane is a fundamental property of life. Until the discovery of the first water channel, aquaporin, it was long assumed that the transport of water was due to simple diffusion through the lipid bilayer membrane that encloses cells. Aquaporin (AQP) molecules were first discovered in the human uterus in 1994, and since then several studies have investigated these channels in the female reproductive system. The expressions of AQPs have been proven in the reproductive system. Their levels are altered during the implantation process, both in the uterus and the fetal cells, and participate in the control of the flow of amniotic fluid. They seem to be very important for the normal placental functions. AQPs are present during parturition, participating in the control of pregnant myometrial contractions and cervical ripening. However, most of the physiological and regulatory roles of AQPs are not clarified in the reproductive tract. Furthermore, no satisfactory knowledge is available about their sensitivities to different drugs. AQP-selective ligands may contribute to the development of new drug candidates and the therapy of several reproductive disorders.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.