SynthesisAmerican journal of human genetics2017
DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in American journal of human genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 15 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 15 pooled it
5.3field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
153 citing papers in PubMed, 15 syntheses or guidelines pooled it, 249 citations in OpenAlex.
- Accelerated epigenetic age in hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Pooled it
- Regulation of nc886 (vtRNA2-1) RNAs is associated with cardiometabolic risk factors and diseases.Clinical epigenetics · 2025Pooled it
- Genome- and epigenome-wide association studies identify susceptibility of CpG sites and regions for metabolic syndrome in a Korean population.Clinical epigenetics · 2024Pooled it
- Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis.Epigenetics · 2023Pooled it
- Epigenome-wide association study of BMI in Black populations from InterGEN and GENOA.Obesity (Silver Spring, Md.) · 2023Pooled it
- Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease.Nature communications · 2022Pooled it
- Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts.Diabetologia · 2022Pooled it
- Meta-analyses identify DNA methylation associated with kidney function and damage.Nature communications · 2021Pooled it
- A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.Nature communications · 2021Pooled it
- Epigenome-Wide Association Study of Thyroid Function Traits Identifies Novel Associations of fT3 With KLF9 and DOT1L.The Journal of clinical endocrinology and metabolism · 2021Pooled it
- Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2020Pooled it
- The role of DNA methylation and histone modifications in blood pressure: a systematic review.Journal of human hypertension · 2019Pooled it
- Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease.Circulation · 2019Pooled it
- Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns.Hypertension (Dallas, Tex. : 1979) · 2019Pooled it
- Mendelian Randomization and the Environmental Epigenetics of Health: a Systematic Review.Current environmental health reports · 2019Pooled it
- Trial
- Hypertension-associated DNA methylation signatures and multi-generational epigenetic clocks in Korean adults.GeroScience · 2026Article
- Genetic Regulation of DNA Methylation and Its Mediating Role in Blood Pressure: A Genome-Wide Twin Study.MedComm · 2026Article
- Nuclear factor IX promotes endometriosis progression through transcriptional activation of tetraspanin-2.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Age-varying DNA methylation patterns associated with blood pressure in mid-to-late adulthood.Clinical epigenetics · 2026Article
93 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
65 authors at 20 institutions in 5 countries.
Melissa A RichardBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA. Electronic address: melissa.a.lee@uth.tmc.edu.
Tianxiao HuanPopulation Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA; Framingham Heart Study, Framingham, MA 01702, USA.
Symen LigthartDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000, the Netherlands.
Rahul GondaliaDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.
Min A JhunDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48108, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Riccardo MarioniCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.
Jincheng ShenDepartment of Population Health Sciences, University of Utah School of Medicine, Salt Lake City, UT 84108, USA.
Pei-Chien TsaiDepartment of Twin Research and Genetic Epidemiology, Kings College London, SE17EH London, UK.
May E MontasserDivision of Endocrinology, Diabetes, and Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Yucheng JiaInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Catriona SymeHospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada.
Elias L SalfatiDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Weihua GuanDepartment of Biostatistics, University of Minnesota, Minneapolis, MN 55454, USA.
Thomas H MosleyDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Jan BresslerHuman Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA.
Alanna C MorrisonHuman Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA.
Chunyu LiuPopulation Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA; Framingham Heart Study, Framingham, MA 01702, USA; Department of Biostatistics, Boston University, Boston, MA 02118, USA.
Michael M MendelsonPopulation Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA; Framingham Heart Study, Framingham, MA 01702, USA; Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.
André G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam 3000, the Netherlands.
Joyce B van MeursDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam 3000, the Netherlands.
BIOS Consortium
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000, the Netherlands.
Guosheng ZhangDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA; Curriculum in Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, NC 27514, USA; Department of Statistics, University of North Carolina, Chapel Hill, NC 27514, USA.
Yun LiDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA.
James D StewartDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA; Carolina Population Center, University of North Carolina, Chapel Hill, NC 27514, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA 98101, USA; Kaiser Permanente Washington Health Research Unit, Seattle, WA 98101, USA.
Yii-Der Ida ChenInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48108, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48108, USA.
Stephen T TurnerDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA.
Devin AbsherHudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.
Stella AslibekyanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Allan F McRaeQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Lifang HouDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Allan C JustDepartment of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Joel D SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Pantel S VokonasVeterans Affairs Normative Aging Study, Veterans Affairs Boston Healthcare System, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, Kings College London, SE17EH London, UK.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, Kings College London, SE17EH London, UK.
Alan ShuldinerDivision of Endocrinology, Diabetes, and Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; The Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
Coleen M DamcottDivision of Endocrinology, Diabetes, and Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Walter PalmasDepartment of Medicine, Columbia University, New York, NY 10032, USA.
Yongmei LiuWake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Tomáš PausDepartments of Psychology and Psychiatry, University of Toronto, Toronto, ON M5S 3G3, Canada; Rotman Research Institute, Baycrest, Toronto, ON M6A 2E1, Canada; Child Mind Institute, New York, NY 10022, USA.
Steve HorvathDepartment of Human Genetics, Gonda Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Zdenka PausovaHospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada; Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Nona SotoodehniaCardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA 98195, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48108, USA.
Donna K ArnettUniversity of Kentucky, College of Public Health, Lexington, KY 40563, USA.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, University of Edinburgh, Edinburgh EH9 8JZ, UK.
Andrea A BaccarelliDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Jordana T BellDepartment of Twin Research and Genetic Epidemiology, Kings College London, SE17EH London, UK.
Eric WhitselDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000, the Netherlands; Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
Daniel LevyPopulation Sciences Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA; Framingham Heart Study, Framingham, MA 01702, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA; Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA. Electronic address: myriam.fornage@uth.tmc.edu.
Erasmus MC · NLUniversity of North Carolina at Chapel Hill · USKing's College London · GBThe Lundquist Institute · USThe University of Texas Health Science Center at Houston · USUniversity of Maryland, Baltimore · USUniversity of Michigan · USUniversity of Toronto · CAUniversity of Washington · USBoston Children's Hospital · USBoston University · USBrown Foundation · USHarvard University · USNational Heart Lung and Blood Institute · USStanford University · USThe University of Queensland · AUUniversity of Alabama at Birmingham · USWake Forest University · USAlzheimer Scotland · GBBaylor College of Medicine · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MUniversity of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2013 to 2026
$19.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MT32 Training Program in Mechanisms and Innovation in Vascular DiseaseT32HL098049 · NHLBI · STANFORD UNIVERSITY · PI Nicholas James Leeper, Philip S Tsao · 2010 to 2026
$6.3MRare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6MAn Integrated Genetic and Epigenetic Approach to Cerebral Small Vessel DiseaseR01NS087541 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A., FORNAGE, MYRIAM · 2014 to 2017
$2.5MEpigenetics of Arteriosclerosis in African American Hypertensive SibshipsR01HL133221 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SMITH, JENNIFER ANN · 2016 to 2019
$2.2MPrenatal Exposure to Endocrine Disrupters, DNA Methylation, and Childhood ObesityR00ES023450 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JUST, ALLAN C. · 2016 to 2018
$747kCirculating Epigenetic Biomarkers for Personalized Cardiovascular Disease PreventionK99HL136875 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI MENDELSON, MICHAEL MAXWELL · 2017 to 2018
$330kBiotechnology and Biological Sciences Research Council BB/F019394/1Medical Research Council MR/K026992/1Medical Research Council MR/L01341X/1Medical Research Council MR/M013111/1NCATS NIH HHS UL1 TR001881NHLBI NIH HHS K99 HL136875NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL133221NHLBI NIH HHS T32 HL098049NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK079626NIEHS NIH HHS R00 ES023450NINDS NIH HHS R01 NS087541
Abstract
Genome-wide association studies have identified hundreds of genetic variants associated with blood pressure (BP), but sequence variation accounts for a small fraction of the phenotypic variance. Epigenetic changes may alter the expression of genes involved in BP regulation and explain part of the missing heritability. We therefore conducted a two-stage meta-analysis of the cross-sectional associations of systolic and diastolic BP with blood-derived genome-wide DNA methylation measured on the Infinium HumanMethylation450 BeadChip in 17,010 individuals of European, African American, and Hispanic ancestry. Of 31 discovery-stage cytosine-phosphate-guanine (CpG) dinucleotides, 13 replicated after Bonferroni correction (discovery: N = 9,828, p < 1.0 × 10
Indexed as
AgedBlood PressureCpG IslandsCross-Sectional StudiesDNA MethylationEpigenesis, GeneticGenetic VariationGenome-Wide Association StudyHumansMendelian Randomization AnalysisMiddle AgedNerve Tissue ProteinsQuantitative Trait LociTetraspaninsNerve Tissue ProteinsTetraspaninsTSPAN2 protein, humanblood pressureDNA methylationepigenome-wide association studygene expressionMendelian randomizationsequence variation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.