Evidence map›Paper›PMID 29200952›Full record

ArticleInternational journal of medical sciences2017

Prognostic significance of high-mobility group box protein 1 genetic polymorphisms in rheumatoid arthritis disease outcome.

Li-Hong Wang, Min-Huan Wu, Po-Chun Chen, Chen-Ming Su, Guohong Xu, Chien-Chung Huang, Chun-Hao Tsai, Yuan-Li Huang, Chih-Hsin Tang

Open access · goldAbstract read
In one paragraph

Article in International journal of medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. International journal of medical sciences · 2019
    Article
  8. Single Nucleotide Polymorphisms inMolecules (Basel, Switzerland) · 2018
    Article
  9. Correlation betweenInternational journal of medical sciences · 2018
    Article
  10. Article
  11. International journal of medical sciences · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Li-Hong WangDepartment of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Min-Huan WuPhysical Education Office, Tunghai University, Taichung, Taiwan.
Po-Chun ChenGraduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan.
Chen-Ming SuDepartment of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Guohong XuDepartment of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Chien-Chung HuangDivision of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
Chun-Hao TsaiSchool of Medicine, China Medical University, Taichung, Taiwan.
Yuan-Li HuangDepartment of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan.
Chih-Hsin TangGraduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan.
Asia University · TWChina Medical University · TWWenzhou Medical University · CNChina Medical University Hospital · TWDongyang People's Hospital · CNTunghai University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a systemic inflammatory disease that causes chronic inflammation of the joints. Analysis of genetic variants offers promise for guiding treatment and improving outcomes in RA. High-mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein found in all mammal eukaryotic cells that participates in several biological functions including immune response, cell survival and apoptosis. We investigated the effects of HMGB1 gene polymorphisms on the risk of RA disease progression in a cohort of Chinese Han individuals. Four single nucleotide polymorphisms (SNPs) from the

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseAdultAgedArthritis, RheumatoidChinaFemaleGenotypeHMGB1 ProteinHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsHMGB1 ProteinHMGB1 protein, humanHMGB1Rheumatoid arthritisSNPSusceptibility.

Identifiers

PMID29200952
PMCPMC5707755
OpenAlexW2770970875

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.