Evidence map›Paper›PMID 29215003›Full record

ArticleNature communications2017

Rhythmic potassium transport regulates the circadian clock in human red blood cells.

Erin A Henslee, Priya Crosby, Stephen J Kitcatt, Jack S W Parry, Andrea Bernardini, Rula G Abdallat, Gabriella Braun, Henry O Fatoyinbo, Esther J Harrison, Rachel S Edgar and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Circadian clock communication during homeostasis and ageing.Nature reviews. Molecular cell biology · 2025
    Review
  8. Review
  9. PERspectives on circadian cell biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Potassium rhythms couple the circadian clock to the cell cycle.bioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Erin A HensleeDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Priya CrosbyMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
Stephen J KitcattDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Jack S W ParryDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Andrea BernardiniDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Rula G AbdallatDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Gabriella BraunDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Henry O FatoyinboDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Esther J HarrisonDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Rachel S EdgarMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
Kai F HoettgesDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Akhilesh B ReddyThe Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Rita I JabrFaculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Malcolm von SchantzFaculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK.ORCID http://orcid.org/0000-0002-9911-9436
John S O'NeillMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK. oneillj@mrc-lmb.cam.ac.uk.ORCID http://orcid.org/0000-0003-2204-6096
Fatima H LabeedDepartment of Mechanical Engineering Sciences, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK. f.labeed@surrey.ac.uk.
University of Surrey · GBMRC Laboratory of Molecular Biology · GBHashemite University · JOThe Francis Crick Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M021556/1Cancer Research UK FC001534Medical Research Council FC001534Medical Research Council MC_UP_1201/4Wellcome TrustWellcome Trust 093734/Z/10/ZWellcome Trust FC001534
6 · The paper itself

Abstract

Circadian rhythms organize many aspects of cell biology and physiology to a daily temporal program that depends on clock gene expression cycles in most mammalian cell types. However, circadian rhythms are also observed in isolated mammalian red blood cells (RBCs), which lack nuclei, suggesting the existence of post-translational cellular clock mechanisms in these cells. Here we show using electrophysiological and pharmacological approaches that human RBCs display circadian regulation of membrane conductance and cytoplasmic conductivity that depends on the cycling of cytoplasmic K

Indexed as

Circadian ClocksCircadian RhythmElectrophysiological PhenomenaErythrocytesHumansPeroxiredoxinsPotassiumRNA, MessengerTranscription, GeneticPeroxiredoxinsPotassiumRNA, Messenger

Identifiers

PMID29215003
PMCPMC5719349
OpenAlexW2772101121

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.