Evidence map›Paper›PMID 29233634›Full record

ArticleJournal of cardiovascular computed tomography

Epicardial adipose tissue density and volume are related to subclinical atherosclerosis, inflammation and major adverse cardiac events in asymptomatic subjects.

Markus Goeller, Stephan Achenbach, Mohamed Marwan, Mhairi K Doris, Sebastien Cadet, Frederic Commandeur, Xi Chen, Piotr J Slomka, Heidi Gransar, J Jane Cao and 6 more

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular computed tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT07178145. Cited by 132 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 1 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07178145 phase4recruiting

MRI of Epicardial Adipose Tissue Composition: Development of Methods and Application to Heart Failure With Preserved Ejection Fraction

Ran2025Enrolled192Registered outcomes6Posted comparisons0ConditionsEpicardial Adipose Tissue, Heart Failure Preserved Ejection FractionArmsGLP-1RA
PMID 22334300PMID 22777847PMID 26527483PMID 26971994PMID 28640452PMID 28837682PMID 18509197PMID 29258509PMID 29773163PMID 30006022PMID 30368904PMID 30402702other papers from this trial
Open the trial in the graph
NCT06784154 recruitingnot on this map

The Association of Ectopic Fat and Cardiovascular Disease in People Living With HIV and General Populations: A Cross Sectional Analysis

TypeobservationalSponsorUniversity of LiverpoolRan2024 to 2027Enrolled100ConditionsCardiometabolic Syndrome, HivArmsNon-interventional
3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 1 synthesis or guideline pooled it, 235 citations in OpenAlex.

  1. Pooled it
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  14. Modifiable Risk Factors in Atrial Fibrillation: Clinical Implications and Pathophysiological Insights.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Markus GoellerBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Internal Medicine 2, University of Erlangen, Erlangen, Germany. Electronic address: Markus.Goeller@uk-erlangen.de.
Stephan AchenbachDepartment of Internal Medicine 2, University of Erlangen, Erlangen, Germany. Electronic address: Stephan.Achenbach@uk-erlangen.de.
Mohamed MarwanDepartment of Internal Medicine 2, University of Erlangen, Erlangen, Germany. Electronic address: Mohamed.Marwan@uk-erlangen.de.
Mhairi K DorisDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Mhairi.Doris@cshs.org.
Sebastien CadetDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Sebastien.Cadet@cshs.org.
Frederic CommandeurBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Frederic.Commandeur@cshs.org.
Xi ChenDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Xi.Chen@cshs.org.
Piotr J SlomkaDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Piotr.Slomka@cshs.org.
Heidi GransarDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Heidi.Gransar@cshs.org.
J Jane CaoDepartment of Cardiology, St Francis Hospital, New York, NY, USA. Electronic address: Jane.Cao@chsli.org.
Nathan D WongDepartment of Medicine, University of California at Irvine, Irvine, USA. Electronic address: ndwong@uci.edu.
Moritz H AlbrechtDepartment of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA. Electronic address: MoritzAlbrecht@gmx.net.
Alan RozanskiDivision of Cardiology, Mount Sinai St Lukes Hospital, New York, NY, USA. Electronic address: ar77md@gmail.com.
Balaji K TamarappooDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Balaji.Tamarappoo@cshs.org.
Daniel S BermanDepartment of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Daniel.Berman@cshs.org.
Damini DeyBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: damini.dey@cshs.org.
Cedars-Sinai Medical Center · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEMedical University of South Carolina · USSt. Francis Hospital · USSt. Luke's Hospital · USUniversity of California, Irvine · US

Funding

Automated quantitative CT imaging of epicardial adipose tissue and risk of cardiac eventsR01HL133616 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI DEY, DAMINI · 2016 to 2019
$2.6M
NHLBI NIH HHS R01 HL133616
6 · The paper itself

Abstract

backgroundWe investigated whether epicardial adipose tissue (EAT) volume and density are related to early atherosclerosis, plaque inflammation and major adverse cardiac events (MACE, cardiac death and myocardial infarction) in asymptomatic subjects.

methodsEAT volume and density were quantified from non-contrast cardiac CT in 456 asymptomatic individuals (age 60.3 ± 8.3; 68% with CCS>0) from the prospective EISNER trial. EAT volume and density were examined in relation to coronary calcium score (CCS), inflammatory biomarkers and MACE.

resultsEAT volume was higher and EAT density lower in subjects with coronary calcium compared to subjects without [89 vs 74 cm

conclusionEAT volume was higher and density lower in subjects with coronary calcium compared to subjects with CCS = 0, with similar EAT volume in CCS<100 and CCS≥100. Lower EAT density and increased EAT volume were associated with coronary calcification, serum levels of plaque inflammatory markers and MACE, suggesting that dysfunctional EAT may be linked to early plaque formation and inflammation.

Indexed as

AdiposityComputed Tomography AngiographyPlaque, AtheroscleroticAdipose TissueAgedAsymptomatic DiseasesBiomarkersCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleHumansInflammationInflammation MediatorsLipidsMaleBiomarkersInflammation MediatorsLipidsEarly subclinical atherosclerosisEAT density and volumeEpicardial adipose tissueInflammatory biomarkersMajor adverse cardiovascular eventsMetabolic abnormality

Identifiers

PMID29233634
PMCPMC5776050
OpenAlexW2771012943

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.