Observational studyJournal of atherosclerosis and thrombosis2018
Rationale and Descriptive Analysis of Specific Health Guidance: the Nationwide Lifestyle Intervention Program Targeting Metabolic Syndrome in Japan.
Observational study in Journal of atherosclerosis and thrombosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 150 citations in OpenAlex.
- Effectiveness of recommendations in promoting the use of mobile health applications in health guidance: a randomized controlled trial.Journal of occupational health · 2025Trial
- The Effect of a mHealth App (KENPO-app) for Specific Health Guidance on Weight Changes in Adults With Obesity and Hypertension: Pilot Randomized Controlled Trial.JMIR mHealth and uHealth · 2023Trial
- Evaluating the Effectiveness of Letter and Telephone Reminders in Promoting the Use of Specific Health Guidance in an At-Risk Population for Metabolic Syndrome in Japan: A Randomized Controlled Trial.International journal of environmental research and public health · 2023Trial
- A Smartphone Healthcare Application,Nutrients · 2022Trial
- Sleep Satisfaction May Modify the Association between Metabolic Syndrome and BMI, Respectively, and Occupational Stress in Japanese Office Workers.International journal of environmental research and public health · 2022Trial
- A Single Motivational Lecture Can Promote Modest Weight Loss: A Randomized Controlled Trial.Obesity facts · 2020Trial
- Association of Weight Loss With Improvement in Metabolic Status Among People Eligible for the Specific Health Guidance Program.Circulation reports · 2026Article
- One-Year Trajectory of Step Counts and Weight Loss in Adults With Overweight/Obesity: Retrospective Cohort Study.JMIR mHealth and uHealth · 2026Article
- Factors Affecting Body Weight/Waist Circumference Changes after Specific Health Guidance for Obese People with CVD Risk Factors in Japan.Journal of atherosclerosis and thrombosis · 2026Article
- Evidence-based Specific Health Guidance for Obese Individuals with Cardiovascular Risk Factors to Reduce Weight and Waist Circumference.Journal of atherosclerosis and thrombosis · 2026Article
- The Specific Health Checkups and Specific Health Guidance Program: A Strategy for the Prevention of Cardiovascular Disease in Japan.Journal of atherosclerosis and thrombosis · 2026Review
- Comorbidities and Concomitant Medications in Middle-Aged Japanese People According to the Charlson Comorbidity Index and Age: Results of the NDB-K7Ps-Study-3.Epidemiologia (Basel, Switzerland) · 2026Article
- Heterogeneous associations of a mobile health-based disease management program on uncontrolled hypertension: A target trial emulation study.PLOS digital health · 2026Article
- Association of changes in body weight and waist circumference with a subsequent risk of developing hypertension in men requiring specific healthcare guidance.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Characterization of individuals in whom body weight loss precedes diabetes onset: a retrospective, observational, longitudinal cohort study based on health checkup in Japan.Endocrine journal · 2026Observational
- Development of a new segmentation algorithm for "precontemplation" stage in lifestyle change among high-risk populations for lifestyle-related diseases.Frontiers in public health · 2026Article
- Lack of knowledge about the hypotensive effects of potassium and dairy: current hypertension-related knowledge and results of a knowledge intervention in Japanese workers.Environmental and occupational health practice · 2026Article
- The impact of awareness of health checkup results on dropout from the specific health guidance programs on metabolic syndrome in the teacher population.Environmental health and preventive medicine · 2026Article
- The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Dietary Characteristics Associated With High Defecation Frequency and Constipation in Japanese Adults: A Cross-Sectional Study.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAll health insurers in Japan are mandated to provide Specific Health Checkups and Specific Health Guidance (SHG) focusing on metabolic syndrome (MetS) in middle-aged adults, beginning in 2008; intensive HG for individuals who have abdominal obesity and two or more additional MetS risk factors, and motivational HG for individuals with one risk factor. The aim of this study is to describe medium-term changes in health indexes for intensive and motivational HG groups using the National Database.
methodsWe compared changes of risk factors and initiation of pharmacological therapy over 3 yr between participants (n=31,790) and nonparticipants (n=189,726) who were eligible for SHG in 2008.
resultsBody weight reduction in intensive HG was 1.98 kg (participants) vs 0.42 kg (nonparticipants) in men (p＜0.01) and 2.25 vs 0.68 kg in women (p＜0.01) after 1 yr. In motivational HG, the respective reduction was 1.40 vs 0.30 kg in men (p＜0.01) and 1.53 vs 0.42 kg in women (p＜0.01). Waist circumference reduction was also greatest among participants in intensive HG (2.34 cm in men and 2.98 cm in women). These reductions were fairly unchanged over 3 yr and accompanied greater improvements in MetS risk factors in participants. We also detected significantly smaller percentages of SHG participants who initiated pharmacological therapy compared with nonparticipants.
conclusionParticipants in SHG showed greater improvements in MetS profiles with proportionally smaller pharmacological treatment initiations than did nonparticipants for 3 yr. Although selection bias may be present, this study suggests SHG would be a feasible strategy to prevent MetS and its sequelae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.