Evidence map›Paper›PMID 29244059›Full record

ReviewThe journals of gerontology. Series A, Biological sciences and medical sciences2018

Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms.

Valeria Tosti, Beatrice Bertozzi, Luigi Fontana

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journals of gerontology. Series A, Biological sciences and medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 427 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
427citing papers in PubMed, 15 pooled it
34.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

427 citing papers in PubMed, 15 syntheses or guidelines pooled it, 714 citations in OpenAlex.

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367 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Valeria TostiDepartment of Medicine, Division of Geriatrics and Nutritional Science, Washington University, St. Louis, Missouri.
Beatrice BertozziDepartment of Medicine, Division of Geriatrics and Nutritional Science, Washington University, St. Louis, Missouri.
Luigi FontanaDepartment of Medicine, Division of Geriatrics and Nutritional Science, Washington University, St. Louis, Missouri.
Washington University in St. Louis · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
NCATS NIH HHS UL1 TR002345NCRR NIH HHS UL1 RR024992
6 · The paper itself

Abstract

Consuming a Mediterranean diet rich in minimally processed plant foods has been associated with a reduced risk of developing multiple chronic diseases and increased life expectancy. Data from several randomized clinic trials have demonstrated a beneficial effect in the primary and secondary prevention of cardiovascular disease, type 2 diabetes, atrial fibrillation, and breast cancer. The exact mechanism by which an increased adherence to the traditional Mediterranean diet exerts its favorable effects is not known. However, accumulating evidence indicates that the five most important adaptations induced by the Mediterranean dietary pattern are: (a) lipid-lowering effect, (b) protection against oxidative stress, inflammation and platelet aggregation, (c) modification of hormones and growth factors involved in the pathogenesis of cancer, (d) inhibition of nutrient sensing pathways by specific amino acid restriction, and (e) gut microbiota-mediated production of metabolites influencing metabolic health. More studies are needed to understand how single modifications of nutrients typical of the Mediterranean diet interact with energy intake, energy expenditure, and the microbiome in modulating the key mechanisms that promote cellular, tissue, and organ health during aging.

Indexed as

Diet, MediterraneanLife ExpectancyAmino AcidsCardiovascular DiseasesHormonesHumansHyperlipidemiasInflammationIntercellular Signaling Peptides and ProteinsMicrobiotaNeoplasmsOxidative StressAmino AcidsHormonesIntercellular Signaling Peptides and Proteins

Identifiers

PMID29244059
PMCPMC7190876
OpenAlexW2774826291

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.