Evidence map›Paper›PMID 29247674›Full record

ArticleNeurotoxicology2018

Developmental exposure to low level ambient ultrafine particle air pollution and cognitive dysfunction.

D A Cory-Slechta, J L Allen, K Conrad, E Marvin, M Sobolewski

Abstract read
In one paragraph

Article in Neurotoxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
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  7. Review
  8. Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium.International journal of molecular sciences · 2024
    Review
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  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

D A Cory-SlechtaDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY 14642, United States. Electronic address: deborah_cory-slechta@urmc.rochester.edu.
J L AllenDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY 14642, United States.
K ConradDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY 14642, United States.
E MarvinDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY 14642, United States.
M SobolewskiDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY 14642, United States.
University of Rochester Medical Center · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PANOS G. GEORGOPOULOS · 1988 to 2026
$47.4M
VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1985 to 2026
$42.8M
Developmental Exposures to Inhaled Air Pollution and the Autism Phenotype in MiceR01ES025541 · NIEHS · UNIVERSITY OF ROCHESTER · PI CORY-SLECHTA, DEBORAH A · 2015 to 2019
$2.2M
CNS Toxicity of Ambient Air Pollution: Postnatal Exposure to Ultrafine ParticlesR21ES019105 · NIEHS · UNIVERSITY OF ROCHESTER · PI CORY-SLECHTA, DEBORAH A · 2010 to 2011
$421k
NIEHS NIH HHS P30 ES001247NIEHS NIH HHS P30 ES005022NIEHS NIH HHS R01 ES025541NIEHS NIH HHS R21 ES019105
6 · The paper itself

Abstract

Developmental exposures to ambient ultrafine particles (UFPs) can produce multiple neuropathological and neurochemical changes that might contribute to persistent alterations in cognitive-type functions. The objective of the current study was to test the hypothesis that developmental UFP exposure produced impairments in learning, memory and impulsive-like behaviors and to determine whether these were selective and thus independent of deficits in other behavioral domains such as motor activity or motivation. Performance on measures of learning (repeated learning), memory (novel object recognition, NOR), impulsive-like behavior (differential reinforcement of low rate (DRL), schedule of reward and delay of reward (DOR)), motor activity (locomotor behavior) and motivation (progressive ratio schedule) were examined in adult mice that had been exposed to concentrated (10-20x) ambient ultrafine particles (CAPS) averaging approximately 45 ug/m

Indexed as

Particle SizeAir PollutantsAir PollutionAnimalsCognitive DysfunctionFemaleInhalation ExposureLocomotionMaleMiceMice, Inbred C57BLMotivationParticulate MatterRandom AllocationAir PollutantsParticulate MatterAir pollutionDelay of rewardDifferential reinforcement of low rateLearningLocomotor activityMotivationProgressive ratioRepeated learningUltrafine particles

Identifiers

PMID29247674
PMCPMC5999548
OpenAlexW2775793556

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.