ArticleExperimental and therapeutic medicine2017
Apelin as a novel drug for treating preeclampsia.
Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reduced uterine perfusion pressure as a model for preeclampsia and fetal growth restriction in murine: a systematic review and meta-analysis.American journal of physiology. Heart and circulatory physiology · 2024Pooled it
- The metabolic implications of maternal exercise: effects on pregnant women and their offspring.Frontiers in nutrition · 2026Review
- Clinicopathological Study of Placentae of Twin Pregnancies with Emphasis on Exploration of Expression of Two Novel Markers, Annexin A5 and Apelin.Turk patoloji dergisi · 2026Observational
- Decoding Apelin: Its Role in Metabolic Programming, Fetal Growth, and Gestational Complications.Children (Basel, Switzerland) · 2024Review
- Effects of apelin on neonatal brain neurogenesis in L-NAME-induced maternal preeclampsia.Scientific reports · 2024Article
- Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention.Journal of reproductive immunology · 2024Review
- Targeting the apelin system for the treatment of cardiovascular diseases.Cardiovascular research · 2023Review
- Comparative Evaluation of Adipokine Metrics for the Diagnosis of Gestational Diabetes Mellitus.International journal of molecular sciences · 2023Article
- Physical exercise for a healthy pregnancy: the role of placentokines and exerkines.The journal of physiological sciences : JPS · 2023Review
- The Apelinergic System in Pregnancy.International journal of molecular sciences · 2023Review
- Is There a Correlation between Apelin and Insulin Concentrations in Early Second Trimester Amniotic Fluid with Fetal Growth Disorders?Journal of clinical medicine · 2023Article
- Preeclampsia and Obesity-The Preventive Role of Exercise.International journal of environmental research and public health · 2023Review
- Apelin as a Candidate for Hypertension Management; a Systematic Review and Meta-Analysis on Animal Studies.Archives of academic emergency medicine · 2022Review
- Possible roles of exercise and apelin against pregnancy complications.Frontiers in endocrinology · 2022Review
- Apelin, APJ, and ELABELA: Role in Placental Function, Pregnancy, and Foetal Development-An Overview.Cells · 2021Review
- Placental Ischemia Says "NO" to Proper NOS-Mediated Control of Vascular Tone and Blood Pressure in Preeclampsia.International journal of molecular sciences · 2021Review
- The Influence of Maternal Obesity on Cell-Free Fetal DNA and Blood Pressure Regulation in Pregnancies with Hypertensive Disorders.Medicina (Kaunas, Lithuania) · 2021Article
- Clinicopathological study of annexin A5 & apelin in pre-eclamptic placentae with emphasis on foetal outcome.The Indian journal of medical research · 2021Observational
- Novel Targets for Hypertension Drug Discovery.Current hypertension reports · 2021Review
- Ameliorative effect of apelin-13 against renal complications in L-NAME-induced preeclampsia in rats.PeerJ · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preeclampsia is a pregnancy-specific disorder of new-onset hypertension and proteinuria after 20 weeks' gestation, often resulting in poor outcome. Previous studies demonstrated that apelin is an endogenous active peptide with visodilation and anti-oxidative stress capabilities. The present study investigated the effects of apelin in a rat model of preeclampsia induced by reduced uterine perfusion pressure (RUPP). Rats with RUPP displayed hypertension and poor pregnancy outcomes, such as decreased fetal and placental weight. Of note, apelin treatment significantly ameliorated the symptoms of preeclampsia, improved the impaired endothelial nitric oxide synthase/nitric oxide signaling and attenuated activation of oxidative stress in RUPP rats. Apelin may be a potential agent for preventing and treating preeclampsia.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.