Evidence map›Paper›PMID 29257106›Full record

ArticleInternational journal of molecular sciences2017

A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder.

Zengyan Xie, Xianyan Yang, Xiaoya Deng, Mingyue Ma, Kunxian Shu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Fibroblast Growth Factors in Depression.Frontiers in pharmacology · 2019
    Review
  7. Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zengyan XieInstitute of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, China. xiezy@cqupt.edu.cn.ORCID 0000-0003-1347-0135
Xianyan YangInstitute of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, China. yxianyan@outlook.com.
Xiaoya DengInstitute of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, China. deng_xiaoya@outlook.com.
Mingyue MaInstitute of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, China. mamingyue@cqupt.edu.cn.ORCID 0000-0002-0186-8800
Kunxian ShuInstitute of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, China. shukx@cqupt.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bipolar disorder is a common and severe mental illness with unsolved pathophysiology. A genome-wide association study (GWAS) has been used to find a number of risk genes, but it is difficult for a GWAS to find genes indirectly associated with a disease. To find core hub genes, we introduce a network analysis after the GWAS was conducted. Six thousand four hundred fifty eight single nucleotide polymorphisms (SNPs) with

Indexed as

Gene Regulatory NetworksPolymorphism, Single NucleotideBipolar DisorderF-Box ProteinsFibroblast Growth FactorsGenome-Wide Association StudyHumansIntracellular Signaling Peptides and ProteinsMethylenetetrahydrofolate Dehydrogenase (NADP)Minor Histocompatibility AntigensF-Box ProteinsFibroblast Growth FactorsIntracellular Signaling Peptides and ProteinsMethylenetetrahydrofolate Dehydrogenase (NADP)Minor Histocompatibility AntigensMTHFD1 protein, humanWDFY2 protein, humanbipolar disorderfunctional enrichment analysisGWASnetwork analysis

Identifiers

PMID29257106
PMCPMC5751362

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.