ArticleCardiovascular diabetology2017
Impaired ventricular filling limits cardiac reserve during submaximal exercise in people with type 2 diabetes.
Article in Cardiovascular diabetology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Cardiorespiratory fitness in individuals with type 2 diabetes mellitus: a systematic review and meta-analysis.Archives of endocrinology and metabolism · 2023Pooled it
- Effects of pioglitazone with and without exercise training on cardiorespiratory fitness and oxygen uptake kinetics in type 2 diabetes.Diabetes, obesity & metabolism · 2025Trial
- Impact of continuous vs. interval training on oxygen extraction and cardiac function during exercise in type 2 diabetes mellitus.European journal of applied physiology · 2022Trial
- Article
- Development of a Physiologically Based Pharmacokinetic Population Model for Diabetic Patients and its Application to Understand Disease-drug-drug Interactions.Clinical pharmacokinetics · 2024Article
- Muscle deoxygenation during ramp incremental cycle exercise in older adults with type 2 diabetes.European journal of applied physiology · 2024Article
- The cardiovascular changes underlying a low cardiac output with exercise in patients with type 2 diabetes mellitus.Frontiers in physiology · 2024Review
- Difference of cardiac rehabilitation in the morning or evening on indexes of left ventricular andAnnals of medicine and surgery (2012) · 2023Article
- Sarco/endoplasmic reticulum calcium ATPase activity is unchanged despite increased myofilament calcium sensitivity in Zucker type 2 diabetic fatty rat heart.Scientific reports · 2022Article
- Intradialysis hypotension and hypertension in patients with end stage kidney disease in Nigeria: risk factors and clinical correlates.Ghana medical journal · 2021Article
- Asymptomatic type 2 diabetes mellitus display a reduced myocardial deformation but adequate response during exercise.European journal of applied physiology · 2021Article
- Clinical outcomes after cardiac rehabilitation in elderly patients with and without diabetes mellitus: The EU-CaRE multicenter cohort study.Cardiovascular diabetology · 2020Observational
- Increased Cardiovascular Response to a 6-Minute Walk Test in People With Type 2 Diabetes.Diabetes spectrum : a publication of the American Diabetes Association · 2020Article
- High-intensity interval training improves metabolic syndrome and body composition in outpatient cardiac rehabilitation patients with myocardial infarction.Cardiovascular diabetology · 2019Observational
- The role of physical activity in the development of first cardiovascular disease event: a tree-structured survival analysis of the Danish ADDITION-PRO cohort.Cardiovascular diabetology · 2018Observational
- Exercise capacity in diabetes mellitus is predicted by activity status and cardiac size rather than cardiac function: a case control study.Cardiovascular diabetology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAttenuated increases in ventricular stroke volume during exercise are common in type 2 diabetes and contribute to reduced aerobic capacity. The purpose of this study was to determine whether impaired ventricular filling or reduced systolic ejection were responsible for the attenuated stroke volume reserve in people with uncomplicated type 2 diabetes.
methodsPeak aerobic capacity and total blood volume were measured in 17 people with diabetes and 16 non-diabetic controls with no evidence of cardiovascular disease. Left ventricular volumes and other systolic and diastolic functional parameters were measured with echocardiography at rest and during semi-recumbent cycle ergometry at 40 and 60% of maximal aerobic power and compared between groups.
resultsPeople with diabetes had reduced peak aerobic capacity and heart rate reserve, and worked at lower workloads than non-diabetic controls. Cardiac output, stroke volume and ejection fraction were not different at rest, but increased less in people with diabetes during exercise. Left ventricular end systolic volume was not different between groups in any condition but end diastolic volume, although not different at rest, was smaller in people with diabetes during exercise. Total blood volume was not different between the groups, and was only moderately associated with left ventricular volumes.
conclusionsPeople with type 2 diabetes exhibit an attenuated increase in stroke volume during exercise attributed to an inability to maintain/increase left ventricular filling volumes at higher heart rates. This study is the first to determine the role of filling in the blunted cardiac reserve in adults with type 2 diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.