ArticleScientific reports2017
Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study.European heart journal · 2023Pooled it
- Pooled it
- Identifying small-effect genetic associations overlooked by the conventional fixed-effect model in a large-scale meta-analysis of coronary artery disease.Bioinformatics (Oxford, England) · 2020Pooled it
- Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies.Nature communications · 2019Pooled it
- Enhancing cardiovascular risk prediction in Asian populations: A machine learning approach integrated with digital health platforms.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Identifying genetic susceptibility loci associated with human coronary artery disease.PloS one · 2025Article
- Deciphering the conformational changes induced by high-risk nsSNPs in β-lactoglobulin.Heliyon · 2024Article
- APOA5 deficiency causes hypertriglyceridemia by reducing amounts of lipoprotein lipase in capillaries.Journal of lipid research · 2024Review
- Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Bangladeshi Atherosclerosis Biobank and Hub: The BANGABANDHU Study.International journal of general medicine · 2024Article
- Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts of lipoprotein lipase in the capillary lumen.The Journal of clinical investigation · 2023Article
- Clinical and Prognostic Value of Non-Fasting Lipoproteins and Apolipoproteins in Chinese Patients with Coronary Heart Disease.Reviews in cardiovascular medicine · 2023Article
- Genetic Factors for Coronary Heart Disease and Their Mechanisms: A Meta-Analysis and Comprehensive Review of Common Variants from Genome-Wide Association Studies.Diagnostics (Basel, Switzerland) · 2022Review
- Gain-of-Function Variants in Lipid Genes Enhance Biological Insight and Point Toward Therapeutic Opportunities.Circulation · 2022Article
- Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function.Scientific reports · 2022Article
- Analysis of 61 SNPs from the CAD specific genomic loci reveals unique set of SNPs as significant markers in the Southern Indian population of Hyderabad.BMC cardiovascular disorders · 2022Article
- Computational Insights into the Deleterious Impacts of Missense Variants onInternational journal of molecular sciences · 2021Article
- Interaction between a haptoglobin genetic variant and coronary artery disease (CAD) risk factors on CAD severity in Singaporean Chinese population.Molecular genetics & genomic medicine · 2020Article
- Association of rs4618210A>G variant inJournal of cardiovascular and thoracic research · 2020Article
- Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 5 institutions in 3 countries.
Yi HanDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore; and Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Rajkumar DorajooGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0001-6608-2051
Xuling ChangDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore; and Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Ling WangGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Chiea-Chuen KhorGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0002-1128-4729
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Yuan ShiSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Yih Chung ThamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Wanting ZhaoSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Miao Ling CheeSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Charumathi SabanayagamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.ORCID 0000-0002-4042-4719
Miao Li CheeSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Nicholas TanSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
E-Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Jianjun LiuGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Daniel Y T GohDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore; and Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Jian-Min YuanDepartment of Epidemiology, Graduate School of Public Health; and University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Woon-Puay KohSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Adrian F LowYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Mark Yan-Yee ChanYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Yechiel FriedlanderSchool of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. yechielf@ekmd.huji.ac.il.
Chew-Kiat HengDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore; and Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore. paehck@nus.edu.sg.
National University of Singapore · SGSingapore National Eye Center · SGAgency for Science, Technology and Research · SGHebrew University of Jerusalem · ILUPMC Hillman Cancer Center · US
Funding
Prospective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0MTHE SINGAPORE COHORT STUDY OF DIET AND CANCERR01CA080205 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, JIAN-MIN · 1999 to 2009
$5.3MCancer epidemiology cohorts in Shanghai and Singapore UM1CA182876 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2014 to 2018
$4.3MNCI NIH HHS R01 CA080205NCI NIH HHS R01 CA144034NCI NIH HHS UM1 CA182876
Abstract
Recent genome-wide association studies (GWAS) have identified multiple loci associated with coronary artery disease (CAD) among predominantly Europeans. However, their relevance to multi-ethnic populations from Southeast Asia is largely unknown. We performed a meta-analysis of four GWAS comprising three Chinese studies and one Malay study (Total N = 2,169 CAD cases and 7,376 controls). Top hits (P < 5 × 10
Indexed as
Mutation, MissensePolymorphism, Single NucleotideAdultAgedAged, 80 and overApolipoprotein A-VAsia, SoutheasternBiomarkersCase-Control StudiesCoronary Artery DiseaseEthnicityFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeAPOA5 protein, humanApolipoprotein A-VBiomarkers
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.