ArticleJournal of neuroinflammation2017
Inflammatory dysregulation of monocytes in pediatric patients with obsessive-compulsive disorder.
Article in Journal of neuroinflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Immune Aberrations in Obsessive-Compulsive Disorder: a Systematic Review and Meta-analysis.Molecular neurobiology · 2019Pooled it
- Vitamin D Deficiency and Obsessive-Compulsive Disorder Severity: A Cross-Sectional Study.Life (Basel, Switzerland) · 2026Article
- Association between epigenetic age acceleration and psychiatric disorders: a bidirectional Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- From menses to ovulation: the immunomodulatory role of monocyte cytokines in menstrual cycle physiology and reproductive health - a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Sex-associated and disease state-dependent monocyte polarization and CNS-trafficking phenotypes in pediatric acute-onset neuropsychiatric syndrome (PANS).Journal of neuroinflammation · 2025Article
- The role of previous streptococcal infections in adult patients with obsessive-compulsive disorder: a research study.CNS spectrums · 2025Article
- Phenomenology of repetitive and restrictive behaviors and sensory phenomena in neurodevelopmental disorders: an exploratory study.BMC psychiatry · 2025Article
- Altered eotaxin-1 and interleukin-34 levels in obsessive-compulsive disorder: a case-control observational study in Bangladesh.Osong public health and research perspectives · 2025Article
- Ketogenic Diet as a Nutritional Metabolic Intervention for Obsessive-Compulsive Disorder: A Narrative Review.Nutrients · 2024Review
- Transient peripheral blood transcriptomic response to ketamine treatment in children with ADNP syndrome.Translational psychiatry · 2024Article
- Viral infections in etiology of mental disorders: a broad analysis of cytokine profile similarities - a narrative review.Frontiers in cellular and infection microbiology · 2024Review
- Exploring the role of interleukin-1β and interleukin-6 in the pathophysiology of obsessive-compulsive disorder.PloS one · 2024Article
- Association of granulocyte macrophage colony-stimulating factor and interleukin-17 levels with obsessive-compulsive disorder: a case-control study findings.Scientific reports · 2023Article
- Cytokine levels reflect tic symptoms more prominently during mild phases.BMC neuroscience · 2023Article
- Obsessive-Compulsive Disorder, PANDAS, and Tourette Syndrome: Immuno-inflammatory Disorders.Advances in experimental medicine and biology · 2023Review
- Anti-Inflammatory Therapy as a Promising Target in Neuropsychiatric Disorders.Advances in experimental medicine and biology · 2023Review
- Pediatric Acute-Onset Neuropsychiatric Syndrome: Current Perspectives.Neuropsychiatric disease and treatment · 2023Review
- Cytokine alterations in pediatric internalizing disorders: Systematic review and exploratory multi-variate meta-analysis.Brain, behavior, & immunity - health · 2022Article
- WNT/β-catenin pathway and circadian rhythms in obsessive-compulsive disorder.Neural regeneration research · 2022Review
- Gene expression study in monocytes: evidence of inflammatory dysregulation in early-onset obsessive-compulsive disorder.Translational psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAlthough the exact etiology of obsessive-compulsive disorder (OCD) is unknown, there is growing evidence of a role for immune dysregulation in the pathophysiology of the disease, especially in the innate immune system including the microglia. To test this hypothesis, we studied inflammatory markers in monocytes from pediatric patients with OCD and from healthy controls.
methodsWe determined the percentages of total monocytes, CD16+ monocytes, and classical (CD14
resultsOCD patients had significantly higher percentages of total monocytes and CD16+ monocytes than healthy controls, mainly due to an increase in the intermediate subset but also in the non-classical monocytes. Monocytes from OCD patients released higher amounts of GM-CSF, IL-1β, IL-6, IL-8, and TNF-α than healthy controls after exposure to LPS. However, there were no significant differences in basal cytokine production or the sensitivity of monocytes to dexamethasone treatment between both groups. Based on monocyte subset distribution and cytokine production after LPS stimulation, patients receiving psychoactive medications seem to have an intermediate inflammatory profile, that is, lower than non-medicated OCD individuals and higher than healthy controls.
conclusionsThese results strongly support the involvement of an enhanced proinflammatory innate immune response in the etiopathogenesis of early-onset OCD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.