Evidence map›Paper›PMID 29284667›Full record

ReviewThe Journal of cell biology2018

Building the right centriole for each cell type.

Jadranka Loncarek, Mónica Bettencourt-Dias

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 106 citations in OpenAlex.

  1. Review
  2. Article
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  12. Seize the engine: Emerging cell cycle targets in breast cancer.Clinical and translational medicine · 2024
    Review
  13. Article
  14. Formation and function of multiciliated cells.The Journal of cell biology · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Jadranka LoncarekCell Cycle Regulation Lab, Gulbenkian Institute of Science, Oeiras, Portugal jadranka.loncarek@nih.gov.ORCID 0000-0003-1879-5473
Mónica Bettencourt-DiasLaboratory of Protein Dynamics and Signaling, National Institutes of Health/Center for Cancer Research/National Cancer Institute-Frederick, Frederick, MD mdias@igc.gulbenkian.pt.ORCID 0000-0003-1987-5598
Instituto Gulbenkian de Ciência · PTNational Institutes of Health · US

Funding

Control of centrosome biogenesisZIABC011459 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LONCAREK, JADRANKA · 2012 to 2025
$16.1M
6 · The paper itself

Abstract

The centriole is a multifunctional structure that organizes centrosomes and cilia and is important for cell signaling, cell cycle progression, polarity, and motility. Defects in centriole number and structure are associated with human diseases including cancer and ciliopathies. Discovery of the centriole dates back to the 19th century. However, recent advances in genetic and biochemical tools, development of high-resolution microscopy, and identification of centriole components have accelerated our understanding of its assembly, function, evolution, and its role in human disease. The centriole is an evolutionarily conserved structure built from highly conserved proteins and is present in all branches of the eukaryotic tree of life. However, centriole number, size, and organization varies among different organisms and even cell types within a single organism, reflecting its cell type-specialized functions. In this review, we provide an overview of our current understanding of centriole biogenesis and how variations around the same theme generate alternatives for centriole formation and function.

Indexed as

AnimalsCentriolesHumans

Identifiers

PMID29284667
PMCPMC5839779
OpenAlexW2777045056

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.