Evidence map›Paper›PMID 29284786›Full record

SynthesisEuropean journal of clinical nutrition2018

Effect of omega-3 long-chain polyunsaturated fatty acid supplementation on heart rate: a meta-analysis of randomized controlled trials.

Khemayanto Hidayat, Jing Yang, Zheng Zhang, Guo-Chong Chen, Li-Qiang Qin, Manfred Eggersdorfer, Weiguo Zhang

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of clinical nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. The Effect of MarineNutrients · 2019
    Trial
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Identification of potential molecular mechanisms and small molecule drugs in myocardial ischemia/reperfusion injury.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020
    Article
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Khemayanto HidayatDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, 215123, China.
Jing YangDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, 215123, China.
Zheng ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, 215123, China.
Guo-Chong ChenDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, 215123, China.
Li-Qiang QinDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, 215123, China. qinliqiang@suda.edu.cn.
Manfred EggersdorferDSM Nutritional Products, Human Nutrition and Health, 4303, Kaiseraugst, Switzerland.
Weiguo ZhangDSM Nutritional Products, Human Nutrition and Health, Beijing, 100020, China. wei-guo.zhang@dsm.com.
Soochow University · CNDSM (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElevated resting heart rate (HR) has emerged as a new risk factor for all-cause and cardiovascular mortality. The effect of marine-derived omega-3 long-chain polyunsaturated fatty acid (n-3 LCPUFAs) supplementation on HR was investigated as an outcome in many clinical trials. The present study was to provide an updated meta-analysis on the HR-slowing effect of n-3 LCPUFAs, and to differentiate the chronotropic effect between eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

methodsPubMed and Cochrane databases were searched for relevant articles examining the effects of n-3 PUFAs on HR through May 2017. A random-effects model was used to generate the pooled effect sizes and 95% confidence intervals (CIs). The pooled effect sizes were presented as weighted mean differences (WMDs).

resultsA total of 51 randomized controlled trials (RCTs) with approximately 3000 participants were included in this meta-analysis. Compared to placebo, n-3 PUFA supplementation mildly but significantly reduced HR (-2.23 bpm; 95% CI: -3.07, -1.40 bpm). Moderate evidence of heterogeneity was observed among included trials (I

conclusionsThe present meta-analysis provides strong clinical evidence demonstrating the effect of heart rate reduction by n-3 LCPUFA supplementation. When DHA or EPA administered alone, heart rate was slowed by DHA rather than by EPA.

Indexed as

Dietary SupplementsHeart RateDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3HumansRandomized Controlled Trials as TopicDocosahexaenoic AcidsEicosapentaenoic Acideicosapentaenoic acid ethyl esterFatty Acids, Omega-3

Identifiers

PMID29284786
PMCPMC5988646
OpenAlexW2776660140

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.