Evidence map›Paper›PMID 29285985›Full record

ReviewNucleus (Austin, Tex.)2018

Discontinuous transcription.

Evgeny Smirnov, Matúš Hornáček, Tomáš Vacík, Dušan Cmarko, Ivan Raška

Abstract readReview
In one paragraph

Review in Nucleus (Austin, Tex.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Archaeal transcription.Transcription · 2020
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Evgeny Smirnova Institute of Biology and Medical Genetics , First Faculty of Medicine , Charles University and General University Hospital in Prague , Prague , Czech Republic.
Matúš Hornáčeka Institute of Biology and Medical Genetics , First Faculty of Medicine , Charles University and General University Hospital in Prague , Prague , Czech Republic.
Tomáš Vacíka Institute of Biology and Medical Genetics , First Faculty of Medicine , Charles University and General University Hospital in Prague , Prague , Czech Republic.
Dušan Cmarkoa Institute of Biology and Medical Genetics , First Faculty of Medicine , Charles University and General University Hospital in Prague , Prague , Czech Republic.
Ivan Raškaa Institute of Biology and Medical Genetics , First Faculty of Medicine , Charles University and General University Hospital in Prague , Prague , Czech Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous studies based on new single-cell and single-gene techniques show that individual genes can be transcribed in short bursts or pulses accompanied by changes in pulsing frequencies. Since so many examples of such discontinuous or fluctuating transcription have been found from prokaryotes to mammals, it now seems to be a common mode of gene expression. In this review we discuss the occurrence of the transcriptional fluctuations, the techniques used for their detection, their putative causes, kinetic characteristics, and probable physiological significance.

Indexed as

AnimalsHumansKineticsTranscription, Geneticburstingdiscontinuous gene expressionkineticsPulsing transcriptiontranscriptional fluctuation

Identifiers

PMID29285985
PMCPMC5973254

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.