Evidence map›Paper›PMID 29314138›Full record

Trial reportClinical endocrinology2018

Ovarian markers and irregular menses among women with type 1 diabetes in the Epidemiology of Diabetes Interventions and Complications study.

C Kim, R S Miller, B H Braffett, Y Pan, V L Arends, A K Saenger, A Barnie, A V Sarma, EDIC Research Group

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

C KimDepartments of Medicine, Obstetrics & Gynecology, and Epidemiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-9237-0532
R S MillerDepartment of Pediatrics, University of Maryland, Baltimore, MD, USA.
B H BraffettThe Biostatistics Center, George Washington University, Rockville, MD, USA.
Y PanThe Biostatistics Center, George Washington University, Rockville, MD, USA.
V L ArendsDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
A K SaengerDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
A BarnieMt. Sinai Hospital, University of Toronto, Toronto, ON, Canada.
A V SarmaDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
EDIC Research Group
George Washington University · USUniversity of Michigan · USUniversity of Minnesota · USMount Sinai Hospital · CAUniversity of Maryland, Baltimore · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · 1986 to 2025
$12.6M
Epidemiology of Diabetes Interventions and Complications (EDIC) StudyU01DK094157 · CASE WESTERN RESERVE UNIVERSITY · 2025 to 2025
$8.0M
Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Biostatistics CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2022 to 2022
$4.3M
NCATS NIH HHS UL1 TR000170NIDDK NIH HHS DP3 DK098129NIDDK NIH HHS P30 DK017047NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176
6 · The paper itself

Abstract

objectiveWomen with type 1 diabetes have increased risk of infertility compared to women without diabetes even after adjustment for irregular menses, but aetiologies are incompletely understood. Our aim was to examine the prevalence of abnormalities in ovarian markers consistent with polycystic ovary syndrome in women with type 1 diabetes and associations with irregular menses and diabetes-specific variables. DESIGN, PATIENTS AND MEASUREMENTS: We conducted a secondary analysis of women in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC), a randomized trial and observational follow-up of intensive insulin therapy for type 1 diabetes. We included women with anti-Müllerian hormone (AMH) measurements among women not using oral contraceptives (n = 187). Initial AMH and testosterone measures were performed between EDIC years 1 and 4. History of irregular menses was assessed annually.

resultsThe median age of women was 35 (interquartile ratio 29, 40) years; 133 (35%) had elevated AMH and 62 (17%) reported irregular menses. Twelve per cent of women had relative elevations in total testosterone. In multivariable models, lower insulin dosages were associated with higher AMH concentrations (P = .0027), but not diabetes duration, glycemic control, body mass index or irregular menses. Neither irregular menses nor diabetes-specific variables were associated with testosterone concentrations.

conclusionsAmong women with type 1 diabetes in their thirties, abnormalities in ovarian markers are common and not associated with irregular menses and thus may partially account for decreased fecundity in women with type 1 diabetes.

Indexed as

AdultAnti-Mullerian HormoneBiomarkersDiabetes Mellitus, Type 1FemaleFollow-Up StudiesHumansInfertility, FemaleInsulinMenstruation DisturbancesOvaryPolycystic Ovary SyndromeAnti-Mullerian HormoneBiomarkersInsulinfertilityovarytype 1 diabeteswomen

Identifiers

PMID29314138
PMCPMC5814334
OpenAlexW2781717097

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.