Evidence map›Paper›PMID 29317343›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2018

Nanoliposomal delivery of cytosolic phospholipase A

Raghavendra Gowda, Saketh S Dinavahi, Soumya Iyer, Shubhadeep Banerjee, Rogerio I Neves, Colette R Pameijer, Gavin P Robertson

Abstract read
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

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  14. Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases ABiochimica et biophysica acta. Molecular and cell biology of lipids · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Raghavendra GowdaDepartment of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA; The Penn State Melanoma and Skin Cancer Center, The Pennsylvania State University College of Medicine, Hershey, PA; Penn State Melanoma Therapeutics Program, The Pennsylvania State University College of Medicine, Hershey, PA; Foreman Foundation for Melanoma Research, The Pennsylvania State University College of Medicine, Hershey, PA.
Saketh S DinavahiDepartment of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA.
Soumya IyerDepartment of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA.
Shubhadeep BanerjeeDepartment of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA.
Rogerio I NevesDepartment of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA; Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, PA; Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, PA; The Penn State Melanoma and Skin Cancer Center, The Pennsylvania State University College of Medicine, Hershey, PA; Penn State Melanoma Therapeutics Program, The Pennsylvania State University College of Medicine, Hershey, PA; Foreman Foundation for Melanoma Research, The Pennsylvania State University College of Medicine, Hershey, PA.
Colette R PameijerDepartment of Surgery, The Pennsylvania State University College of Medicine, Hershey, PA; The Penn State Melanoma and Skin Cancer Center, The Pennsylvania State University College of Medicine, Hershey, PA; Penn State Melanoma Therapeutics Program, The Pennsylvania State University College of Medicine, Hershey, PA.
Gavin P RobertsonDepartment of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA; Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA; Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, PA; Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, PA; The Penn State Melanoma and Skin Cancer Center, The Pennsylvania State University College of Medicine, Hershey, PA; Penn State Melanoma Therapeutics Program, The Pennsylvania State University College of Medicine, Hershey, PA; Foreman Foundation for Melanoma Research, The Pennsylvania State University College of Medicine, Hershey, PA. Electronic address: gpr11@psu.edu.
Pennsylvania State University · USPenn State Milton S. Hershey Medical Center · US

Funding

Targeted Chemoprevention for MelanomaR01CA136667 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ROBERTSON, GAVIN P. · 2010 to 2014
$2.1M
Akt3 Signaling as a Therapeutic TargetR01CA127892 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ROBERTSON, GAVIN P. · 2008 to 2012
$1.5M
Synergistically Acting Targeted Therapeutics for MelanomaR01CA138634 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ROBERTSON, GAVIN P. · 2010 to 2014
$1.5M
NCI NIH HHS R01 CA127892NCI NIH HHS R01 CA136667NCI NIH HHS R01 CA138634
6 · The paper itself

Abstract

Drug resistance and toxicity are major limitations of cancer treatment and frequently occurs during melanoma therapy. Nanotechnology can decrease drug resistance by improving drug delivery, with limited toxicity. This study details the development of nanoparticles containing arachidonyl trifluoromethyl ketone (ATK), a cytosolic phospholipase A

Indexed as

Drug Delivery SystemsAnimalsArachidonic AcidsCell ProliferationFemaleHumansLiposomesMelanomaMiceMice, NudeNanoparticlesPhospholipase A2 InhibitorsPhospholipases A2, CytosolicTumor Cells, CulturedArachidonic AcidsarachidonyltrifluoromethaneLiposomesPhospholipase A2 InhibitorsPhospholipases A2, CytosolicArachidonyl trifluoromethyl ketone and nanoliposomescyclooxygenaseInflammatory cancerLipid mediatorsPhospholipase A(2)

Identifiers

PMID29317343
PMCPMC5899023
OpenAlexW2782090199

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.