ArticleJournal of cellular physiology2018
Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis.
Open access · bronzeAbstract read
In one paragraph
Article in Journal of cellular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- Monoallelic Gene Expression: Stochastic or Clonal? From Detection to Mechanisms and Clinical Significance.International journal of molecular sciences · 2026Review
- A novel duplication frameshift mutation in the BAG3 gene in a patient with dilated cardiomyopathy.BMC cardiovascular disorders · 2026Article
- An mTOR-Tfeb-Fabp7a Axis Ameliorates bag3 Cardiomyopathy via Decelerating Cardiac Aging.Aging cell · 2025Article
- Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co-Occurrence of P63A and P380SJournal of the American Heart Association · 2023Article
- Regulated cell death pathways in cardiomyopathy.Acta pharmacologica Sinica · 2023Review
- Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart.JACC. Basic to translational science · 2023Article
- Transcriptome studies of inherited dilated cardiomyopathies.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Review
- Article
- BAG3: Nature's Quintessential Multi-Functional Protein Functions as a Ubiquitous Intra-Cellular Glue.Cells · 2023Review
- Cardiac-Specific Expression of Cre Recombinase Leads to Age-Related Cardiac Dysfunction Associated with Tumor-like Growth of Atrial Cardiomyocyte and Ventricular Fibrosis and Ferroptosis.International journal of molecular sciences · 2023Article
- Comprehensive review on gene mutations contributing to dilated cardiomyopathy.Frontiers in cardiovascular medicine · 2023Review
- Genetics of BAG3: A Paradigm for Developing Precision Therapies for Dilated Cardiomyopathies.Journal of the American Heart Association · 2022Review
- Understanding the molecular basis of cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2022Review
- Review
- Review
- Locus specific epigenetic modalities of random allelic expression imbalance.Nature communications · 2021Article
- Therapeutic targeting of BAG3: considering its complexity in cancer and heart disease.The Journal of clinical investigation · 2021Review
- BAG3 expression and sarcomere localization in the human heart are linked to HSF-1 and are differentially affected by sex and disease.American journal of physiology. Heart and circulatory physiology · 2021Article
- Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover.Nature communications · 2021Article
- An Adult Mouse Model of Dilated Cardiomyopathy Caused by Inducible Cardiac-SpecificInternational journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Valerie D MyersDepartment of Medicine, Lewis Katz School of Medicine at Philadelphia, Philadelphia, Pennsylvania.
Dhanendra TomarCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Muniswamy MadeshCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
JuFang WangCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Jianliang SongCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Xue-Qian ZhangCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Manish K GuptaDepartment of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Farzaneh G TahrirDepartment of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Jennifer GordonDepartment of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Joseph M McClungDepartment of Physiology, Brody School of Medicine, East Carolina University, Greeneville, North Carolina.
Christopher D KontosDivision of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
Kamel KhaliliDepartment of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Joseph Y CheungDepartment of Medicine, Lewis Katz School of Medicine at Philadelphia, Philadelphia, Pennsylvania.
Arthur M FeldmanDepartment of Medicine, Lewis Katz School of Medicine at Philadelphia, Philadelphia, Pennsylvania.ORCID http://orcid.org/0000-0001-8351-9569
Temple University · USSchool District of Philadelphia · USDuke Medical Center · USEast Carolina University · US
Funding
Targeted Cancer Therapeutics and Heart Failure: Mechanisms and Post-injury RepairP01HL091799 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI KOCH, WALTER J. · 2008 to 2018
$23.1MCoordination of Pathophysiologic Endothelial Cell Signaling by ROSR01HL086699 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2008 to 2018
$4.3MInvolvement of BAG3 in HIV-1 induced cardiomyopathyR01HL123093 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CHEUNG, JOSEPH Y, FELDMAN, ARTHUR M · 2014 to 2018
$3.7MEXERCISE TRAINING IN POSTINFARCT HEARTR01HL058672 · NHLBI · WEIS CENTER FOR RESEARCH-GEISINGER CLINC · PI CHEUNG, JOSEPH Y · 1998 to 2012
$3.6MSpectral revelations of mitochondrial Ca2+ flux interactomeR01GM109882 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2014 to 2022
$3.3MPhospholemman and Cardiac ContractilityR01HL074854 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CHEUNG, JOSEPH Y · 2005 to 2014
$2.8MGenetic Determinants of Limb Pathology in Peripheral Artery DiseaseR01HL125695 · NHLBI · EAST CAROLINA UNIVERSITY · PI MCCLUNG, JOSEPH MATTHEW · 2015 to 2019
$1.9MInhibition of MCUR1-MCU mediated mitochondrial Ca2+ uptake prevents I/R injuryR01HL119306 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI MUNISWAMY, MADESH · 2014 to 2017
$1.6MSkeletal Muscle and Vascular Remodeling in Peripheral Artery DiseaseR01HL124444 · NHLBI · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 2015 to 2017
$1.4MMultiphoton upgrade of confocal microscope for live organ and tissue imagingS10RR022511 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI MUNISWAMY, MADESH · 2007 to 2007
$500kNCRR NIH HHS S10 RR022511NHLBI NIH HHS P01 HL091799NHLBI NIH HHS R01 HL058672NHLBI NIH HHS R01 HL074854NHLBI NIH HHS R01 HL086699NHLBI NIH HHS R01 HL119306NHLBI NIH HHS R01 HL123093NHLBI NIH HHS R01 HL124444NHLBI NIH HHS R01 HL125695NIGMS NIH HHS R01 GM109882
Abstract
Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid protein that is found predominantly in the heart, skeletal muscle, and many cancers. Deletions and truncations in BAG3 that result in haplo-insufficiency have been associated with the development of dilated cardiomyopathy. To study the cellular and molecular events attributable to BAG3 haplo-insufficiency we generated a mouse in which one allele of BAG3 was flanked by loxP recombination sites (BAG3
Indexed as
Adaptor Proteins, Signal TransducingAdrenergic AgentsAnimalsApoptosisApoptosis Regulatory ProteinsAutophagyCalciumCardiomyopathy, DilatedHeart FailureIsoproterenolMaleMiceMice, Inbred C57BLMyocytes, CardiacPhenotypeProto-Oncogene Proteins c-bcl-2Adaptor Proteins, Signal TransducingAdrenergic AgentsApoptosis Regulatory ProteinsBag3 protein, mouseBcl2 protein, mouseCalciumIsoproterenolProto-Oncogene Proteins c-bcl-2Receptors, Adrenergic, betaBAG3cardiomyopathy (DCM)genetic mutationhaplo-insufficiency
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.