Evidence map›Paper›PMID 29325562›Full record

ArticleCardiovascular diabetology2018

Increased epicardial adipose tissue thickness is a predictor of new-onset diabetes mellitus in patients with coronary artery disease treated with high-intensity statins.

Jeehoon Kang, Young-Chan Kim, Jin Joo Park, Sehun Kim, Si-Hyuck Kang, Young Jin Cho, Yeonyee E Yoon, Il-Young Oh, Chang-Hwan Yoon, Jung-Won Suh and 4 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  12. Novel imaging biomarkers: epicardial adipose tissue evaluation.The British journal of radiology · 2020 · on this map
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Jeehoon KangDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro173 Beongil, Bundang, Seongnam, Gyeonggi, 13620, South Korea.
Young-Chan KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Jin Joo ParkDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro173 Beongil, Bundang, Seongnam, Gyeonggi, 13620, South Korea.
Sehun KimDivision of Cardiology, Hallym University Hangang Sacred Heart Hospital, Seoul, South Korea.
Si-Hyuck KangDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro173 Beongil, Bundang, Seongnam, Gyeonggi, 13620, South Korea.
Young Jin ChoDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro173 Beongil, Bundang, Seongnam, Gyeonggi, 13620, South Korea.
Yeonyee E YoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro173 Beongil, Bundang, Seongnam, Gyeonggi, 13620, South Korea.
Il-Young OhDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro173 Beongil, Bundang, Seongnam, Gyeonggi, 13620, South Korea.
Chang-Hwan YoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro173 Beongil, Bundang, Seongnam, Gyeonggi, 13620, South Korea.
Jung-Won SuhDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro173 Beongil, Bundang, Seongnam, Gyeonggi, 13620, South Korea.
Young-Seok ChoDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro173 Beongil, Bundang, Seongnam, Gyeonggi, 13620, South Korea. flammeus1@gmail.com.ORCID 0000-0001-9944-9868
Tae-Jin YounDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro173 Beongil, Bundang, Seongnam, Gyeonggi, 13620, South Korea.
In-Ho ChaeDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro173 Beongil, Bundang, Seongnam, Gyeonggi, 13620, South Korea.
Dong-Ju ChoiDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumiro173 Beongil, Bundang, Seongnam, Gyeonggi, 13620, South Korea.
Seoul National University Bundang Hospital · KRSeoul National University · KRSeoul National University Hospital · KRHallym University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStatins are widely used for lipid lowering in patients with coronary artery disease (CAD), but increasing evidence indicates an association between statin use and new-onset of diabetes mellitus (NODM). Epicardial adipose tissue (EAT) refers to the visceral fat surrounding the heart, which is associated with metabolic diseases. We sought to determine the association between EAT thickness and NODM in CAD patients treated with high-intensity statins.

methodsWe conducted a retrospective medical record review of CAD patients treated with high-intensity statins for at least 6 months after percutaneous coronary intervention performed between January 2009 and June 2013 at Seoul National University Bundang Hospital. EAT thickness was measured by echocardiography using standardized methods.

resultsA total of 321 patients were enrolled, who received high-intensity statins for a mean of 952 days; atorvastatin 40 mg in 204 patients (63.6%), atorvastatin 80 mg in 57 patients (17.8%), and rosuvastatin 20 mg in 60 patients (18.7%). During the follow-up period of 3.9 ± 1.7 years, NODM occurred in 40 patients (12.5%). On Cox proportional-hazard regression analysis, EAT thickness at systole [for each 1 mm: hazard ratio (HR) 1.580; 95% confidence interval (CI) 1.346-1.854; P < 0.001] and prediabetes at baseline (HR 4.321; 95% CI 1.998-9.349; P < 0.001) were the only independent predictors of NODM. Using binary cutoff values derived from the receiver operating characteristic curve analysis, EAT thickness at systole larger than 5.0 mm had an HR of 3.402 (95% CI 1.751-6.611, P < 0.001), sensitivity of 52.5%, and specificity of 80.8% for predicting NODM. Also, patients with EAT thickness ≥ 5 mm and prediabetes at baseline had a 12.0-times higher risk of developing NODM compared to the risk noted in patients with EAT thickness < 5 mm and normal glucose tolerance at baseline.

conclusionEpicardial adipose tissue thickness at systole is a consistent independent predictor of NODM in patients with CAD treated with high-intensity statins. Such predictors may help physicians plan adequate surveillance for early detection of NODM.

Indexed as

EchocardiographyAdipose TissueAgedAtorvastatinCoronary Artery DiseaseDiabetes MellitusFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPericardiumPredictive Value of TestsRetrospective StudiesRisk FactorsRosuvastatin CalciumAtorvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsRosuvastatin CalciumCoronary artery diseaseEchocardiographyEpicardial adipose tissueNew-onset diabetes mellitusStatin

Identifiers

PMID29325562
PMCPMC5763639
OpenAlexW2782590681

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.