Evidence map›Paper›PMID 29326315›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2018

Plasma n-3 and n-6 Fatty Acids Are Differentially Related to Carotid Plaque and Its Progression: The Multi-Ethnic Study of Atherosclerosis.

Brian T Steffen, Weihua Guan, James H Stein, Mathew C Tattersall, Joel D Kaufman, Veit Sandfort, Moyses Szklo, Michael Y Tsai

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
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  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Brian T SteffenFrom the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (B.T.S., M.Y.T.); Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis (W.G.); Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison (J.H.S., M.C.T.); Department of Epidemiology, School of Public Health, University of Washington, Seattle (J.D.K.); Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD (V.S.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.S.).
Weihua GuanFrom the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (B.T.S., M.Y.T.); Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis (W.G.); Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison (J.H.S., M.C.T.); Department of Epidemiology, School of Public Health, University of Washington, Seattle (J.D.K.); Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD (V.S.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.S.).
James H SteinFrom the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (B.T.S., M.Y.T.); Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis (W.G.); Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison (J.H.S., M.C.T.); Department of Epidemiology, School of Public Health, University of Washington, Seattle (J.D.K.); Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD (V.S.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.S.).
Mathew C TattersallFrom the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (B.T.S., M.Y.T.); Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis (W.G.); Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison (J.H.S., M.C.T.); Department of Epidemiology, School of Public Health, University of Washington, Seattle (J.D.K.); Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD (V.S.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.S.).
Joel D KaufmanFrom the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (B.T.S., M.Y.T.); Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis (W.G.); Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison (J.H.S., M.C.T.); Department of Epidemiology, School of Public Health, University of Washington, Seattle (J.D.K.); Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD (V.S.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.S.).
Veit SandfortFrom the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (B.T.S., M.Y.T.); Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis (W.G.); Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison (J.H.S., M.C.T.); Department of Epidemiology, School of Public Health, University of Washington, Seattle (J.D.K.); Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD (V.S.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.S.).
Moyses SzkloFrom the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (B.T.S., M.Y.T.); Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis (W.G.); Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison (J.H.S., M.C.T.); Department of Epidemiology, School of Public Health, University of Washington, Seattle (J.D.K.); Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD (V.S.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.S.).
Michael Y TsaiFrom the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (B.T.S., M.Y.T.); Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis (W.G.); Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison (J.H.S., M.C.T.); Department of Epidemiology, School of Public Health, University of Washington, Seattle (J.D.K.); Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD (V.S.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.S.). tsaix001@umn.edu.
University of Minnesota · USUniversity of Washington · USNational Institutes of Health Clinical Center · USUniversity of Wisconsin–Madison · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095163 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1999 to 2001
$443k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095168 · HC · JOHNS HOPKINS UNIVERSITY · PI BLUEMKE, DAVID A. · 1999 to 2000
$375k
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-N01HC95159-268095159N01HC095159 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 1999 to 2006
$304k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169
6 · The paper itself

Abstract

objectiveω-3 (n-3) fatty acids (FAs) have long been considered healthful dietary components, yet recent clinical trials have questioned their cardiovascular benefits. By contrast, the ω-6 (n-6) FAs have been considered harmful, proatherogenic macronutrients, despite an absence of empirical evidence supporting this hypothesis. We aimed to determine whether plasma n-3 and n-6 FAs are related to risk of carotid plaque and its progression in 3327 participants of MESA (Multi-Ethnic Study of Atherosclerosis). APPROACH AND

resultsCarotid plaque was assessed using ultrasonography at baseline and after a median period of 9.5 years. Plasma phospholipid n-3 and n-6 FAs were determined using gas chromatography-flame ionization detection. Relative risk regression analyses assessed the relations of FAs with the presence or progression of carotid plaque adjusted for typical cardiovascular disease risk factors. At baseline, it was found that participants in the fourth quartile of n-3 docosahexaenoic acid showed a 9% lower risk of carotid plaque (

conclusionsThese findings support docosahexaenoic acid as an atheroprotective macronutrient, whereas null findings for n-6 FAs challenge the view that they promote atherosclerosis.

Indexed as

Plaque, AtheroscleroticAgedAged, 80 and overBiomarkersCarotid ArteriesCarotid Artery DiseasesDisease ProgressionDocosahexaenoic AcidsFatty Acids, Omega-6FemaleFlame IonizationHumansMaleMiddle AgedPrognosisProspective StudiesBiomarkersDocosahexaenoic AcidsFatty Acids, Omega-6atherosclerosisfatty acidshumansprospective studiesrisk factors

Identifiers

PMID29326315
PMCPMC5823763
OpenAlexW2784082962

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.