Evidence map›Paper›PMID 29330337›Full record

ArticleJournal of medical genetics2018

Role of germline aberrations affecting

Robbert D A Weren, Rachel S van der Post, Ingrid P Vogelaar, J Han van Krieken, Liesbeth Spruijt, Jan Lubinski, Anna Jakubowska, Urszula Teodorczyk, Cora M Aalfs, Liselotte P van Hest and 16 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Review
  5. A Japanese family of hereditary diffuse gastric cancer with a germline pathogenic variant of CTNN1A detected via comprehensive genome profiling.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
    Article
  6. Review
  7. Frequency ofCancers · 2023
    Article
  8. Review
  9. Hereditary Diffuse Gastric Cancer: A 2022 Update.Journal of personalized medicine · 2022
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Clinical implications of CTNNA1 germline mutations in asymptomatic carriers.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 16 institutions in 7 countries.

Robbert D A Weren *Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.
Rachel S van der Post *Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands.
Ingrid P VogelaarDepartment of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.
J Han van KriekenDepartment of Pathology, Radboud university medical center, Nijmegen, The Netherlands.
Liesbeth SpruijtDepartment of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.
Jan LubinskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Urszula TeodorczykDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Cora M AalfsDepartment of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands.
Liselotte P van HestDepartment of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands.
Carla OliveiraExpression Regulation in Cancer Group, Instituto de Investigação e Inovação em Saúde, Porto, Portugal.
Eveline J KampingDepartment of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.
Hans K SchackertDepartment of Surgical Research, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Guglielmina N RanzaniDepartment of Biology and Biotechnology, University of Pavia, Pavia, Italy.
Encarna B Gómez GarcíaDepartment of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
Frederik J HesDepartment of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-3025-0882
Elke Holinski-FederMedizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany.
Maurizio GenuardiInstitute of Genomic Medicine, Catholic University of the Sacred Heart, Milan, Italy.
Margreet G E M AusemsDepartment of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
Rolf H SijmonsDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Anja WagnerDepartment of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Lizet E van der KolkFamily Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Annemieke CatsDepartment of Gastrointestinal Oncology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Inga BjørnevollDepartment of Medical Genetics, St Olav's Hospital, Trondheim, Norway.
Nicoline HoogerbruggeDepartment of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.
Marjolijn J L LigtenbergDepartment of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.
Radboud University Nijmegen · NLPomeranian Medical University · PLThe Netherlands Cancer Institute · NLAmsterdam UMC Location University of Amsterdam · NLAmsterdam UMC Location Vrije Universiteit Amsterdam · NLErasmus MC · NLLeiden University Medical Center · NLLMU Klinikum · DEMaastricht University · NLSt Olav's University Hospital · NOUniversidade do Porto · PTUniversità Cattolica del Sacro Cuore · ITUniversity Hospital Carl Gustav Carus · DEUniversity Medical Center Groningen · NLUniversity Medical Center Utrecht · NLUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn approximately 10% of all gastric cancer (GC) cases, a heritable cause is suspected. A subset of these cases have a causative germline

methodsWe sequenced a large cohort of unexplained young and/or familial patients with GC (n=286) without a

resultsPredicted deleterious germline variants were not encountered in

conclusionsBased on our results

Indexed as

AdultAgedalpha CateninAntigens, CDCadherinsCohort StudiesEuropeFemaleGenetic Predisposition to DiseaseGerm-Line MutationHigh-Throughput Nucleotide SequencingHumansMaleMAP Kinase Kinase KinasesMiddle AgedMyeloid Differentiation Factor 88alpha CateninAntigens, CDCadherinsCDH1 protein, humanCTNNA1 protein, humanMAP kinase kinase kinase 6MAP Kinase Kinase KinasesMYD88 protein, humanMyeloid Differentiation Factor 88cancer: gastricctnna1 – map3k6 – myd88heritabilitynext generation sequencing

Identifiers

PMID29330337
PMCPMC6161648
OpenAlexW2783562498

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.