Evidence map›Paper›PMID 29331272›Full record

SynthesisJACC. Heart failure2018

High-Sensitivity Cardiac Troponin and New-Onset Heart Failure: A Systematic Review and Meta-Analysis of 67,063 Patients With 4,165 Incident Heart Failure Events.

Jonathan D W Evans, Stephen J H Dobbin, Stephen J Pettit, Emanuele Di Angelantonio, Peter Willeit

2 registry-linked trialsOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in JACC. Heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT04056039. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04056039 phase2completed

Efficacy of Atorvastatin vs Colchicine in Decrease of Troponin I of High Sensitivity as a Biomarker of Myocardial Damage in Patients With Rheumatoid Arthritis With Severe Activity.

Ran2018Enrolled60Registered outcomes3Posted comparisons0ConditionsArthritis, Rheumatoid, Cardiovascular DiseasesArmsAtorvastatin, Colchicine
PMID 27580061PMID 27965879PMID 28610589PMID 29322198PMID 29352092PMID 29353098PMID 29417936PMID 29554376PMID 11358070PMID 15189396PMID 16972704PMID 18926169other papers from this trial
Open the trial in the graph
NCT05112731 terminatednot on this mapstarted 2022, after this paper: background citation

Action of Glycation and Inflammation in Operative Ischemic Heart Disease

TypeobservationalSponsorGEK SrlRan2022 to 2023Enrolled16ConditionsMyocardial Infarction, Glycation End Products, Advanced, Inflammation, Heart InjuriesArmsBAFF and MGO
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
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  7. Cardiac Biomarkers in Chronic Kidney Disease: Signal or Noise?Clinical journal of the American Society of Nephrology : CJASN · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Jonathan D W EvansDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Transplant Unit, Papworth Hospitals NHS Foundation Trust, Papworth Everard, Cambridge, United Kingdom.
Stephen J H DobbinDepartment of Cardiology, Golden Jubilee National Hospital, Clydebank, Glasgow, United Kingdom.
Stephen J PettitTransplant Unit, Papworth Hospitals NHS Foundation Trust, Papworth Everard, Cambridge, United Kingdom.
Emanuele Di AngelantonioDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, United Kingdom; NHS Blood and Transplant, Cambridge, United Kingdom.
Peter WilleitDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: peter.willeit@i-med.ac.at.
Golden Jubilee National Hospital · GBInnsbruck Medical University · ATNHS Blood and Transplant · GBPapworth Hospital NHS Foundation Trust · GBUniversity of Cambridge · GB

Funding

DYNAMICS OF TRANSITION TO VENTRICULAR FIBRILLATIONF32HL008014 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SAXBERG, BO E · 1990 to 1990
–
British Heart Foundation RG/08/014/24067Medical Research Council MR/L003120/1
6 · The paper itself

Abstract

objectivesThe aim of this study was to systematically collate and appraise the available evidence regarding the association between high-sensitivity cardiac troponin (hs-cTn) and incident heart failure (HF) and the added value of hs-cTn in HF prediction.

backgroundIdentification of subjects at high risk for HF and early risk factor modification with medications such as angiotensin-converting enzyme inhibitors may delay the onset of HF. Hs-cTn has been suggested as a prognostic marker for the incidence of first-ever HF in asymptomatic subjects.

methodsPubMed, Embase, and Web of Science were systematically searched for prospective cohort studies published before January 2017 that reported associations between hs-cTn and incident HF in subjects without baseline HF. Study-specific multivariate-adjusted hazard ratios (HRs) were pooled using random-effects meta-analysis.

resultsData were collated from 16 studies with a total of 67,063 subjects and 4,165 incident HF events. The average age was 57 years, and 47% were women. Study quality was high (Newcastle-Ottawa score 8.2 of 9). In a comparison of participants in the top third with those in the bottom third of baseline values of hs-cTn, the pooled multivariate-adjusted HR for incident HF was 2.09 (95% confidence interval [CI]: 1.76 to 2.48; p < 0.001). Between-study heterogeneity was high, with an I

conclusionsAvailable prospective studies indicate a strong association of hs-cTn with the risk of first-ever HF and significant improvements in HF prediction.

Indexed as

AgedBiomarkersFemaleHeart FailureHumansMaleMiddle AgedMyocardial InfarctionTroponinBiomarkersTroponinbiomarkersheart failuremeta-analysisrisk prediction

Identifiers

PMID29331272
OpenAlexW2783150604

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.