Evidence map›Paper›PMID 29340971›Full record

ArticleJournal of endocrinological investigation2018

Denosumab or oral bisphosphonates in primary osteoporosis: a "real-life" study.

E Cairoli, S Palmieri, G Goggi, L Roggero, M Arosio, I Chiodini, C Eller-Vainicher

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. State of the art in osteoporosis risk assessment and treatment.Journal of endocrinological investigation · 2019
    Review
  3. Article
  4. Article
  5. Adverse effects of media reports on the treatment of osteoporosis.Journal of endocrinological investigation · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

E CairoliUnit of Endocrinology, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Padiglione Granelli, Via Francesco Sforza 35, 20122, Milan, Italy.
S PalmieriDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
G GoggiDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
L RoggeroUnit of Endocrinology, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Padiglione Granelli, Via Francesco Sforza 35, 20122, Milan, Italy.
M ArosioUnit of Endocrinology, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Padiglione Granelli, Via Francesco Sforza 35, 20122, Milan, Italy.
I ChiodiniUnit of Endocrinology, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Padiglione Granelli, Via Francesco Sforza 35, 20122, Milan, Italy. iacopo.chiodini@policlinico.mi.it.
C Eller-VainicherUnit of Endocrinology, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Padiglione Granelli, Via Francesco Sforza 35, 20122, Milan, Italy.
University of Milan · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the response to denosumab (DMAb) therapy with that of oral bisphosphonate (BISPH) treatment in postmenopausal women with primary osteoporosis (PO).

methodsIn this retrospective study, we compared data of 75 PO female patients treated for 24 months with DMab (DMAb Group, age 72.6 ± 8.9 years) with those of 75 PO patients treated with oral bisphosphonates (BISPH Group), matched for age, body mass index, femoral bone mineral density (BMD), prevalent fragility fractures and familiar history of hip fracture. In all subjects at baseline and after 24 months we assessed the calcium-phosphorous metabolism parameters, BMD at lumbar spine (LS-BMD) and femoral neck (FN-BMD) by dual X-ray absorptiometry and the morphometric vertebral fractures by radiograph. The patients were considered inadequate responders in the presence of ≥ 2 incident fragility fractures and/or a decrease in BMD greater than the least significant change (LS 2.8%, FN 5.9%).

resultsAfter 24 months, the DMab Group showed a greater ALP decrease (- 22.8 ± 18.2%), a higher LS-BMD and FN-BMD increase (6.6 ± 6.9 and 4.4 ± 8.2%, respectively) and a lower number of patients with an incident fracture (8%) and with an inadequate response (6.7%) than BISPH Group (- 14.9 ± 15.3, 2.5 ± 4.3, 1.9 ± 4.5, 21.3 and 22.7%, respectively, p < 0.05 for all comparisons). The inadequate response was 4.5-fold more likely in BISPH Group than in DMab one (p = 0.027), regardless of possible confounders.

conclusionsIn postmenopausal PO females, denosumab was more effective than oral bisphosphonates in increasing BMD and reducing bone turnover and the number of inadequate responder patients.

Indexed as

Administration, OralAgedAged, 80 and overBone Density Conservation AgentsDenosumabDiphosphonatesFemaleFollow-Up StudiesHumansMaleMiddle AgedOsteoporosis, PostmenopausalPrognosisRetrospective StudiesBone Density Conservation AgentsDenosumabDiphosphonatesBone mineral densityDenosumabFragility fracturesOral bisphosphonates

Identifiers

PMID29340971
OpenAlexW2783340856

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.