Evidence map›Paper›PMID 29343294›Full record

ReviewJournal of cardiothoracic surgery2018

Effect of glycaemic control on complications following cardiac surgery: literature review.

M Navaratnarajah, R Rea, R Evans, F Gibson, C Antoniades, A Keiralla, M Demosthenous, G Kassimis, G Krasopoulos

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of cardiothoracic surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04393636 (Randomized Controlled Trial of Digital Cardiac Counseling in Patients With Delayed Cardiac Surgical Treatment Due to Covid-19 Pandemic), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04393636 nacompletednot on this mapstarted 2020, after this paper: background citation

Randomized Controlled Trial of Digital Cardiac Counseling in Patients With Delayed Cardiac Surgical Treatment Due to Covid-19 Pandemic (DCC Trial)

TypeinterventionalSponsorAcademisch Ziekenhuis MaastrichtRan2020 to 2024Enrolled394ConditionsCardiovascular Diseases, Cardiovascular Risk FactorArmsDigital cardiac Counseling
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. The Use of Sodium-Glucose Cotransporter-2 Inhibitors in Coronary Revascularization: Where Are We Now? A Systematic Review.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024
    Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Mitochondrial Dysfunction in Cardiac Surgery.Anesthesiology clinics · 2025
    Review
  6. Article
  7. Glycated Haemoglobin (HbAJournal of clinical medicine · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Mitochondrial Dysfunction in Cardiac Surgery.Anesthesiology clinics · 2019
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

M NavaratnarajahOxford Heart Centre, John Radcliffe Hospital, Headley Way, Oxfordshire, OX3 9DU, UK. manoraj.navaratnarajah@doctors.org.uk.
R ReaOxford Heart Centre, John Radcliffe Hospital, Headley Way, Oxfordshire, OX3 9DU, UK.
R EvansOxford Heart Centre, John Radcliffe Hospital, Headley Way, Oxfordshire, OX3 9DU, UK.
F GibsonOxford Heart Centre, John Radcliffe Hospital, Headley Way, Oxfordshire, OX3 9DU, UK.
C AntoniadesOxford Heart Centre, John Radcliffe Hospital, Headley Way, Oxfordshire, OX3 9DU, UK.
A KeirallaOxford Heart Centre, John Radcliffe Hospital, Headley Way, Oxfordshire, OX3 9DU, UK.
M DemosthenousOxford Heart Centre, John Radcliffe Hospital, Headley Way, Oxfordshire, OX3 9DU, UK.
G KassimisOxford Heart Centre, John Radcliffe Hospital, Headley Way, Oxfordshire, OX3 9DU, UK.
G KrasopoulosOxford Heart Centre, John Radcliffe Hospital, Headley Way, Oxfordshire, OX3 9DU, UK.
John Radcliffe Hospital · GB

Funding

British Heart Foundation FS/16/15/32047British Heart Foundation PG/13/56/30383
6 · The paper itself

Abstract

introductionNo uniform consensus in the UK or Europe exists, for glycaemic management of patients with Diabetes or pre-diabetes undergoing cardiac surgery.

objective[i] Determine the relationship between glycaemic control and cardiac surgical outcomes; [ii] Compare current vs gold standard management of patients with Diabetes or pre-diabetes undergoing cardiac surgery.

methodsSearches of MEDLINE, NHS Evidence and Web of Science databases were completed. Articles were limited to those in English, German and French. No date limit was enforced.13,232 articles were identified on initial literature review, and 50 relevant papers included in this review.

resultsNo national standards for glycaemic control prior to cardiac surgery were identified. Upto 30% of cardiac surgical patients have undiagnosed Diabetes. Cardiac surgical patients without Diabetes with pre-operative hyperglycaemia have a 1 year mortality double that of patients with normoglyacemia, and equivalent to patients already diagnosed with Diabetes. Pre- and peri-operative hyperglycaemia is associated with worse outcomes. Evidence regarding tight glycaemic control vs moderate glycaemic control is conflicting. Tight control may be more effective in patients without Diabetes with pre-/peri-operative hyperglycaemia, and moderate control appears more effective in patients with pre-existing Diabetes. Patients with well controlled Diabetes may achieve comparable outcomes to patients without Diabetes with similar glycaemic control.

conclusionsPre / peri-operative hyperglycaemia is associated with worse outcomes in both patients with, and without Diabetes undergoing CABG. This review supports the pre-operative screening, and optimisation of glycaemic control in patients undergoing cardiac surgery. Optimal glycaemic management remains unclear and clear guidelines are needed.

Indexed as

Blood GlucoseCoronary Artery BypassDiabetes Mellitus, Type 2HumansHyperglycemiaPostoperative ComplicationsPreoperative CareBlood GlucoseCABGCardiac surgeryDiabetes

Identifiers

PMID29343294
PMCPMC5773148
OpenAlexW2785597862

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.