Evidence map›Paper›PMID 29345807›Full record

ArticleAngewandte Chemie (International ed. in English)2018

Targeting a Dark Excited State of HIV-1 Nucleocapsid by Antiretroviral Thioesters Revealed by NMR Spectroscopy.

Lalit Deshmukh, Vitali Tugarinov, Daniel H Appella, G Marius Clore

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. 5-Thiohistidine N-Acetyltransferase from Proteiniphilum Saccharofermentans.Chembiochem : a European journal of chemical biology · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Conformational exchange at a CStructure (London, England : 1993) · 2023
    Article
  9. Article
  10. Review
  11. The A39G FF domain folds on a volcano-shaped free energy surface via separate pathways.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. Article
  13. Measuring radiofrequency fields in NMR spectroscopy using offset-dependent nutation profiles.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2021
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Photoactivated Polymersome Nanomotors: Traversing Biological Barriers.Angewandte Chemie (International ed. in English) · 2020
    Article
  20. A CEST NMR experiment to obtain glycineJournal of biomolecular NMR · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lalit DeshmukhLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892-0520, USA.
Vitali TugarinovLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892-0520, USA.
Daniel H AppellaLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892-0830, USA.
G Marius CloreLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892-0520, USA.ORCID 0000-0003-3809-1027

Funding

Structure and Dynamics Of Macromolecules In Solution By NMRZIADK029023 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CLORE, GIDEON · 2009 to 2025
$41.5M
Small Molecular Inactivators of HIVZIADK075135 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI APPELLA, DANIEL H · 2016 to 2025
$7.2M
NMR STUDIES OF THREE-DIMENSIONAL STRUCTURE OF MACROMOLECULES IN SOLUTIONZ01DK029023 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CLORE, G. MARIUS · 1988 to 2008
$949k
Intramural NIH HHS Z01 DK029023
6 · The paper itself

Abstract

HIV-1 nucleocapsid (NCp7) is a two Cys

Indexed as

Anti-Retroviral AgentsEstersgag Gene Products, Human Immunodeficiency VirusMagnetic Resonance SpectroscopyMolecular StructureStructure-Activity RelationshipSulfhydryl CompoundsAnti-Retroviral AgentsEstersgag Gene Products, Human Immunodeficiency VirusNCP7 protein, Human immunodeficiency virus 1Sulfhydryl Compoundsantiretroviralsconformational exchangeHIV-1 nucleocapsidrelaxation dispersionzinc

Identifiers

PMID29345807
PMCPMC6034507

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.