Evidence map›Paper›PMID 29347987›Full record

Observational studyCritical care (London, England)2018

Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study.

Etienne Gayat, Alain Cariou, Nicolas Deye, Antoine Vieillard-Baron, Samir Jaber, Charles Damoisel, Qin Lu, Xavier Monnet, Isabelle Rennuit, Elie Azoulay and 21 more

3 registry-linked trialsAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07025629 phase3recruitingstarted 2025, after this paper: background citation

Dapagliflozin for Cardio-renal Protection After ICU Discharge: A Prospective, Randomized, Double Blinded, Multicenter Study: "DAPA-ICU Trial"

Ran2025Enrolled600Registered outcomes19Posted comparisons0ConditionsHeart Failure and Chronic Kidney Disease Post-ICUArmsDapagliflozin 10 MG Oral Tablet [Farxiga], One tablet of placebo of dapagliflozin 10 mg
PMID 30424892PMID 32516543PMID 32877652PMID 30045823PMID 27391020PMID 31009585PMID 32492305other papers from this trial
Open the trial in the graph
NCT01367093 completednot on this map

French and EuRopean Outcome Registry in Intensive Care Unit

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2011 to 2015Enrolled2,137ConditionsIntensive Care Unit Syndrome, Tracheal Intubation Morbidity
NCT06845865 recruitingnot on this mapstarted 2025, after this paper: background citation

Measurement of Intestinal Permeability in Intensive Care Patients With Single or Multiple Organ Failure

TypeobservationalSponsorDirection Centrale du Service de Santé des ArméesRan2025 to 2029Enrolled126ConditionsMultivisceral Failure Syndrome, Monovisceral Failure, Infection in ICUArmsenteric dyed solution
3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Etienne GayatDepartment of Anesthesiology, Critical Care and Burn Unit, Hôpitaux Universitaires Saint Louis-Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot-Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France. etienne.gayat@aphp.fr.ORCID 0000-0002-3334-3849
Alain CariouMedical Intensive Care Unit, Cochin University Hospital, Assistance Publique-Hôpitaux de Paris, Paris Descartes University, Paris Cardiovascular Research Center-INSERM U970 (PARCC), Paris Sudden Death Expertise Center, Paris, France.
Nicolas DeyeMedical Intensive Care Unit, Hôpitaux Universitaires Saint Louis-Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot-Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France.
Antoine Vieillard-BaronIntensive Care Unit, University Hospital Ambroise Paré, Assistance Publique-Hopitaux de Paris, 26930, Boulogne-Billancourt, France.
Samir JaberIntensive Care Unit, Anaesthesia and Critical Care Department, Saint Eloi Teaching Hospital, Centre Hospitalier Universitaire Montpellier, Montpellier University, Montpellier, France.
Charles DamoiselDepartment of Anesthesiology, Critical Care and Burn Unit, Hôpitaux Universitaires Saint Louis-Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot-Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France.
Qin LuMultidisciplinary Intensive Care Unit, Department of Anesthesiology and Critical Care Medicine, La Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, UPMC Paris 6, Paris, France.
Xavier MonnetMedical Intensive Care Unit, Bicêtre Hospital, Paris-Sud University Hospitals, Inserm UMR_S999, Paris-Sud University, Le Kremlin-Bicêtre, France.
Isabelle RennuitDepartment of Anesthesiology and Critical Care, Beaujon Hospital, Assistance Publique Hôpitaux de Paris University, Clichy, France.
Elie AzoulayMedical Intensive Care Unit, Hôpital Saint-Louis, ECSTRA Team, Biostatistics and Clinical Epidemiology, UMR 1153 (Center of Epidemiology and Biostatistics Sorbonne Paris Cité, CRESS), INSERM, Université Paris Diderot Sorbonne, Paris, France.
Marc LéoneService d'anesthésie et de réanimation, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.
Heikel OueslatiDepartment of Anesthesiology, Critical Care and Burn Unit, Hôpitaux Universitaires Saint Louis-Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot-Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France.
Bertrand GuidetService de Réanimation Médicale, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France.
Diane FriedmanGeneral Intensive Care, Raymond Poincaré University Hosptal, Assistance Publique-Hopitaux de Paris, Garches, France.
Antoine TesnièreDepartment of Anesthesiology and Intensive Care, Cochin University Hospital, Assistance Publique-Hôpitaux de Paris, Paris Descartes University, Paris Cardiovascular Research Center-INSERM U970 (PARCC), Paris Sudden Death Expertise Center, Paris, France.
Romain SonnevilleDepartment of Intensive Care Medicine and Infectious Diseases, Univ Paris Diderot, Sorbonne Paris Cité, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude, Paris, France.
Philippe MontraversDepartment of Anesthesiology and Intensive Care, Bichat University Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot-Paris 7, Sorbonne Paris Cité, Paris, France.
Sébastien Pili-FlouryDepartment of Anesthesiology and Intensive Care Medicine, University Hospital of Besancon, 25000, Besancon, France.
Jean-Yves LefrantDepartment of Anesthesiology, Emergency and Critical Care Medicine, Nimes University Hospital, 30029, Nîmes, France.
Jacques DuranteauDépartement d'Anesthésie-Réanimation, Hôpital de Bicêtre, Université Paris-Sud, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, Paris, France.
Pierre-François LaterreMedical-Surgical Intensive Care Unit, Cliniques Saint-Luc, Brussels, Belgium.
Nicolas BrechotMedical Intensive Care Unit, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne Pierre-Marie Curie University Paris, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition and CIC 1421-Paris Est, Paris, France.
Karine ChevreulURC-Eco, Assistance Publique-Hôpitaux de Paris, Sorbonne Paris Cité, Université Paris Diderot, ECEVE, INSERM, Paris, France.
Morgane MichelDepartment of Anesthesiology and Critical Care Medicine, Hôpital Européen Georges Pompidou, APHP, Université Paris Descartes, Sorbonne Paris Cite, Paris, France.
Bernard CholleyService de Biochimie, Hôpitaux Universitaires Saint Louis-Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot-Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France.
Matthieu LegrandDepartment of Anesthesiology, Critical Care and Burn Unit, Hôpitaux Universitaires Saint Louis-Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot-Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France.
Jean-Marie LaunayService de Biochimie, Hôpitaux Universitaires Saint Louis-Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot-Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France.
Eric VicautUnité de Recherche Clinique, Hôpitaux Universitaires Saint Louis-Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot-Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France.
Mervyn SingerBloomsbury Institute of Intensive Care Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK.
Matthieu Resche-RigonService de Biostatistique et Information Médicale, Hôpitaux Universitaires Saint Louis-Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot-Paris 7, Sorbonne Paris Cité, ECSTRA Team, INSERM, Paris, France.
Alexandre MebazaaDepartment of Anesthesiology, Critical Care and Burn Unit, Hôpitaux Universitaires Saint Louis-Lariboisière, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot-Paris 7, Sorbonne Paris Cité, UMR-S 942, INSERM, Paris, France.

Funding

PHRC National AON 10-216
6 · The paper itself

Abstract

backgroundIntensive care unit (ICU) survivors have reduced long-term survival compared to the general population. Identifying parameters at ICU discharge that are associated with poor long-term outcomes may prove useful in targeting an at-risk population. The main objective of the study was to identify clinical and biological determinants of death in the year following ICU discharge.

methodsFROG-ICU was a prospective, observational, multicenter cohort study of ICU survivors followed 1 year after discharge, including 21 medical, surgical or mixed ICUs in France and Belgium. All consecutive patients admitted to intensive care with a requirement for invasive mechanical ventilation and/or vasoactive drug support for more than 24 h following ICU admission and discharged from ICU were included. The main outcome measure was all-cause mortality at 1 year after ICU discharge. Clinical and biological parameters on ICU discharge were measured, including the circulating cardiovascular biomarkers N-terminal pro-B type natriuretic peptide, high-sensitive troponin I, bioactive-adrenomedullin and soluble-ST2. Socioeconomic status was assessed using a validated deprivation index (FDep).

resultsOf 1570 patients discharged alive from the ICU, 333 (21%) died over the following year. Multivariable analysis identified age, comorbidity, red blood cell transfusion, ICU length of stay and abnormalities in common clinical factors at the time of ICU discharge (low systolic blood pressure, temperature, total protein, platelet and white cell count) as independent factors associated with 1-year mortality. Elevated biomarkers of cardiac and vascular failure independently associated with 1-year death when they are added to multivariable model, with an almost 3-fold increase in the risk of death when combined (adjusted odds ratio 2.84 (95% confidence interval 1.73-4.65), p < 0.001).

conclusionsThe FROG-ICU study identified, at the time of ICU discharge, potentially actionable clinical and biological factors associated with poor long-term outcome after ICU discharge. Those factors may guide discharge planning and directed interventions.

trial registrationClinicalTrials.gov NCT01367093 . Registered on 6 June 2011.

Indexed as

Time FactorsAgedBelgiumCohort StudiesCritical IllnessFemaleFranceHospitalizationHospital MortalityHumansIntensive Care UnitsLength of StayMaleMiddle AgedOdds RatioOutcome Assessment, Health CareVasoconstrictor AgentsBiomarkersDischargeLong-term survivalPost-intensive care syndromeScore

Identifiers

PMID29347987
PMCPMC5774139

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.