ArticleScience (New York, N.Y.)2018
Detection and localization of surgically resectable cancers with a multi-analyte blood test.
6 registry-linked trialsAbstract readEvaluation Study
In one paragraph
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 1,492 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,492citing papers in PubMed, 7 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lung Health Check Biomarker Study
Gastric Cancer Detection by Liquid Biopsy in Peripheral Blood: A Prospective Study
Assessment of a Novel Blood Test in Early Detection of the Five Common Cancers Based on the Investigation of the Circulating Tumour DNA
Pancreatic Cancer Detection by Liquid Biopsy in Peripheral Blood: A Prospective Study
Pancreatic Cancer Detection by Liquid Biopsy in Peripheral Blood: A Prospective Study
Evaluation of a Rapid Test for the Detection of Methylation Profiles (Methylscape) in Various Body Fluids as a Universal Biomarker for Cancer Detection and Monitoring
Who cites it
1,492 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Postoperative ctDNA-Guided Adjuvant Therapy in Resected Colorectal Cancer: A Systematic Review and Meta-analysis of Prognostic Validity Versus Treatment-Decision Utility.Journal of gastrointestinal cancer · 2026Pooled it
- AGA Clinical Practice Update on Risk Stratification and Emerging Surveillance Strategies for Hepatocellular Carcinoma: Expert Review.Gastroenterology · 2026Guideline
- [Liquid Biopsy Revolutionizes the Precise Management of Tumors Across the Entire Course: Current Situation and Future Prospects].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Pooled it
- Blood-Based Circulating Tumor DNA for Early Detection of Colorectal Cancer: A Systematic Review and Meta-Analysis.Digestive diseases (Basel, Switzerland) · 2026Pooled it
- Liquid biopsy and health-related quality of life in cancers: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Toward noninvasive precision: a meta-analysis of photoacoustic spectroscopy in breast cancer.Lasers in medical science · 2025Pooled it
- Predictive Effectiveness of Circulating Tumor DNA in Recurrent Early-Stage Non-Small Cell Lung Cancer: An Updated Meta-Analysis.JCO precision oncology · 2025Pooled it
- Non-invasive screening in hereditary cancer: a randomized controlled trial to test cell-free DNA-based early detection in the CHARM consortium.European journal of human genetics : EJHG · 2026Trial
- Comparison of the Cox Proportional Hazards Model and Random Survival Forest Algorithm for Predicting Patient-Specific Survival Probabilities in Clinical Trial Data.Biometrical journal. Biometrische Zeitschrift · 2026Article
- Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence.Nature medicine · 2026Article
- Predictors of perceived value of multi-cancer early detection testing: a national PRECEDE-PROCEED framework study.Cancer causes & control : CCC · 2026Article
- Liquid biopsy for early detection of pancreatic ductal adenocarcinoma.Nature medicine · 2026Article
- Development and validation of a serum peptidomic signature for early detection of asymptomatic ovarian cancer: A multi-center prospective study.Cell reports. Medicine · 2026Article
- Beyond the Needle: Is Liquid Biopsy the Future of Veterinary Medicine?International journal of molecular sciences · 2026Review
- The RNA cargo of plasma-derived extracellular vesicles in mCRPC patients captures cancer cells and tumor microenvironment signals.bioRxiv : the preprint server for biology · 2026Article
- Identification of a G-quadruplex-forming cell-free DNA fragment as a biomarker for the precise diagnosis of hepatocellular carcinoma.Chemical science · 2026Article
- Advancing the applications of liquid biopsies in oncology.Nature reviews. Genetics · 2026Review
- Beyond Detection Limits: Integrated Biosensors for Molecular Diagnostics, Longitudinal Monitoring, and Clinical Translation.Biosensors · 2026Review
- Epigenetic Profiling for Early Detection and Treatment Response Monitoring in Non-Small Cell Lung Cancer: Protocol for a Prospective Translational Biomarker Study.JMIR research protocols · 2026Article
- Multi-omics-driven precision medicine.iMeta · 2026Review
1,432 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
42 authors.
Joshua D CohenLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-1158-5668
Lu LiDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0002-1920-4965
Yuxuan WangLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-2932-6042
Christopher ThoburnSidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-7743-9183
Bahman AfsariDivision of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
Ludmila DanilovaDivision of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.ORCID 0000-0003-2813-3094
Christopher DouvilleLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-2510-4151
Ammar A JavedDepartment of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.ORCID 0000-0002-5463-5250
Fay WongLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-9759-3778
Austin MattoxLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-7567-5542
Ralph H HrubanSidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Christopher L WolfgangDepartment of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.ORCID 0000-0002-8717-0373
Michael G GogginsSidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Marco Dal MolinSol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Tian-Li WangSidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Richard RodenSidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-2506-0195
Alison P KleinSidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-2737-8399
Janine PtakLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-1934-8739
Lisa DobbynLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-3159-189X
Joy SchaeferLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-6788-8989
Natalie SillimanLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-5198-9037
Maria PopoliLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Joshua T VogelsteinInstitute for Computational Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
James D BrowneDepartment of Computer Science, Johns Hopkins University Whiting School of Engineering, Baltimore, MD 21218, USA.
Robert E SchoenDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0001-7153-2766
Randall E BrandDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0002-4136-3313
Jeanne TieDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3021, Australia.ORCID 0000-0001-9244-2057
Peter GibbsDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3021, Australia.
Hui-Li WongDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3021, Australia.ORCID 0000-0003-3803-2107
Aaron S MansfieldDivision of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0002-9483-6903
Jin JenDivision of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55902, USA.ORCID 0000-0002-8790-9836
Samir M HanashSheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Massimo FalconiDivision of Pancreatic Surgery, Department of Surgery, San Raffaele Scientific Institute Research Hospital, 20132 Milan, Italy.
Peter J AllenDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Shibin ZhouLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-1941-4425
Chetan BettegowdaLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Luis A DiazLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-7079-8914
Cristian TomasettiSidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ctomasetti@jhu.edu amlennon@jhmi.edu kinzlke@jhmi.edu bertvog@gmail.com npapado1@jhmi.edu.ORCID 0000-0003-3277-4804
Kenneth W KinzlerLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ctomasetti@jhu.edu amlennon@jhmi.edu kinzlke@jhmi.edu bertvog@gmail.com npapado1@jhmi.edu.ORCID 0000-0001-5591-1176
Bert VogelsteinLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ctomasetti@jhu.edu amlennon@jhmi.edu kinzlke@jhmi.edu bertvog@gmail.com npapado1@jhmi.edu.ORCID 0000-0003-0766-3854
Anne Marie LennonSidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ctomasetti@jhu.edu amlennon@jhmi.edu kinzlke@jhmi.edu bertvog@gmail.com npapado1@jhmi.edu.ORCID 0000-0001-8957-3945
Nickolas PapadopoulosLudwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. ctomasetti@jhu.edu amlennon@jhmi.edu kinzlke@jhmi.edu bertvog@gmail.com npapado1@jhmi.edu.ORCID 0000-0001-7135-7451
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTranslational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI JAFFEE, ELIZABETH M. · 1993 to 2022
$54.6MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2MTissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI MUKHOPADHYAY, DEBABRATA · 2004 to 2018
$32.7MTraining Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7MRefinement and Discovery of Nuclear Matrix Protein Markers for Colorectal CancerU01CA152753 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KINZLER, KENNETH W., SCHOEN, ROBERT E. · 2010 to 2021
$6.8MDevelopment of in vitro diagnostic multivariate index assay using liquid-based cervical cytology specimen and/or serum/plasma biomarkers for the detection of early stage or low-volume ovarian cancerU01CA200469 · NCI · JOHNS HOPKINS UNIVERSITY · PI SHIH, IE-MING, ZHANG, ZHEN · 2016 to 2021
$2.9MModeling Ribosomal Control, Function and AssemblyR01GM073095 · NIGMS · IOWA STATE UNIVERSITY · PI JERNIGAN, ROBERT L · 2006 to 2009
$1.0MCOMMUNITY-BASED APPROACHES TO TOBACCO CONTROLF32CA069731 · NCI · STANFORD UNIVERSITY · PI RIBISL, KURT M. · 1996 to 1997
–Howard Hughes Medical InstituteNCI NIH HHS F32 CA069731NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA062924NCI NIH HHS P50 CA102701NCI NIH HHS U01 CA152753NCI NIH HHS U01 CA200469NIGMS NIH HHS R01 GM073095NIGMS NIH HHS T32 GM007309NIGMS NIH HHS T32 GM008752
Abstract
Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69 to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was greater than 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients.
Indexed as
Hematologic TestsCirculating Tumor DNACosts and Cost AnalysisEarly Detection of CancerHumansMutationNeoplasm ProteinsNeoplasmsPolymerase Chain ReactionCirculating Tumor DNANeoplasm Proteins
Identifiers
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Registered trials
NCT04957433ClinicalTrials.gov
NCT05224596ClinicalTrials.gov
NCT05227261ClinicalTrials.gov
NCT05495685ClinicalTrials.gov
NCT05556603ClinicalTrials.gov
NCT07741435ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.