Evidence map›Paper›PMID 29349576›Full record

ArticleMolecular neurobiology2018

Prep1 Deficiency Affects Olfactory Perception and Feeding Behavior by Impairing BDNF-TrkB Mediated Neurotrophic Signaling.

Serena Ricci, Davide Viggiano, Ilaria Cimmino, Giuseppe Perruolo, Serena Cabaro, Antonietta Liotti, Francesca Fiory, Rosa Spinelli, Angelina Di Carlo, Francesco Beguinot and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Deciphering GRINA/Lifeguard1: Nuclear Location, CaInternational journal of molecular sciences · 2019
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Serena RicciDepartment of Translational Medical Science, "Federico II" University of Naples and URT "Genomics of Diabetes", Institute of Experimental Endocrinology and Oncology of CNR, Via Pansini 5, 80131, Naples, Italy.
Davide ViggianoDepartment of Medicine and Health Science, University of Molise, Campobasso, Italy.
Ilaria CimminoDepartment of Translational Medical Science, "Federico II" University of Naples and URT "Genomics of Diabetes", Institute of Experimental Endocrinology and Oncology of CNR, Via Pansini 5, 80131, Naples, Italy.
Giuseppe PerruoloDepartment of Translational Medical Science, "Federico II" University of Naples and URT "Genomics of Diabetes", Institute of Experimental Endocrinology and Oncology of CNR, Via Pansini 5, 80131, Naples, Italy.
Serena CabaroDepartment of Translational Medical Science, "Federico II" University of Naples and URT "Genomics of Diabetes", Institute of Experimental Endocrinology and Oncology of CNR, Via Pansini 5, 80131, Naples, Italy.
Antonietta LiottiDepartment of Translational Medical Science, "Federico II" University of Naples and URT "Genomics of Diabetes", Institute of Experimental Endocrinology and Oncology of CNR, Via Pansini 5, 80131, Naples, Italy.
Francesca FioryDepartment of Translational Medical Science, "Federico II" University of Naples and URT "Genomics of Diabetes", Institute of Experimental Endocrinology and Oncology of CNR, Via Pansini 5, 80131, Naples, Italy.
Rosa SpinelliDepartment of Translational Medical Science, "Federico II" University of Naples and URT "Genomics of Diabetes", Institute of Experimental Endocrinology and Oncology of CNR, Via Pansini 5, 80131, Naples, Italy.
Angelina Di CarloDepartment of Medico-Surgical Sciences and Biotechnologies, University of Rome "La Sapienza", Latina, Italy.
Francesco BeguinotDepartment of Translational Medical Science, "Federico II" University of Naples and URT "Genomics of Diabetes", Institute of Experimental Endocrinology and Oncology of CNR, Via Pansini 5, 80131, Naples, Italy.
Pietro FormisanoDepartment of Translational Medical Science, "Federico II" University of Naples and URT "Genomics of Diabetes", Institute of Experimental Endocrinology and Oncology of CNR, Via Pansini 5, 80131, Naples, Italy. fpietro@unina.it.ORCID http://orcid.org/0000-0001-7020-6870
Francesco OrienteDepartment of Translational Medical Science, "Federico II" University of Naples and URT "Genomics of Diabetes", Institute of Experimental Endocrinology and Oncology of CNR, Via Pansini 5, 80131, Naples, Italy.
Institute for Experimental Endocrinology and Oncology · ITFederico II University Hospital · ITSapienza University of Rome · ITUniversity of Molise · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prep1 is a homeodomain transcription factor which has an important role in hindbrain development. Prep1 expression is also kept in adult mouse brain and in particular within the olfactory bulbs. Moreover, many Prep1 neurons co-localize with Calbindin-positive periglomerular interneurons in olfactory glomerular layer. However, Prep1 function in this brain region is still unknown. In this study, we show that Prep1 hypomorphic heterozygous (Prep1

Indexed as

Feeding BehaviorOlfactory PerceptionSignal TransductionAnimalsBehavior, AnimalBrainBrain-Derived Neurotrophic FactorCell Line, TumorHomeodomain ProteinsMice, Inbred C57BLNeuronsReceptor, trkBStaining and LabelingBrain-Derived Neurotrophic FactorHomeodomain ProteinsPknox1 protein, mouseReceptor, trkBBDNFCalbindinOlfactory bulbPrep1TrkB

Identifiers

PMID29349576
PMCPMC6061220
OpenAlexW2785073531

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.