ArticleHormones and behavior2018
Endocrine active metals, prenatal stress and enhanced neurobehavioral disruption.
Article in Hormones and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Exploring the association between metal(loid)s and human semen quality: a preliminary case study in a petrochemical complex.Environmental science and pollution research international · 2025Article
- Long-Term Effect of Early-Life Arsenic Exposure on Morning Plasma Cortisol in Adults from Antofagasta, Chile.medRxiv : the preprint server for health sciences · 2025Article
- Cumulative risk assessment as the pathway to public health protection for behavioral neurotoxicity.Neurotoxicology · 2025Review
- Identifying studies evaluating susceptibility factors for chemical health assessments: A case study focused on methylmercury developmental neurotoxicity.Environment international · 2025Article
- Endocrine disruptors, aryl hydrocarbon receptor and cortisol secretion.Journal of endocrinological investigation · 2024Review
- Single-cell RNA sequencing reveals placental response under environmental stress.Nature communications · 2024Article
- Adolescent endocrine disrupting chemical exposure and academic achievement.Environmental research · 2023Article
- The Single and Combined Effects of Prenatal Nonchemical Stressors and Lead Exposure on Neurodevelopmental Outcomes in Toddlers: Results from the CCREOH Environmental Epidemiologic Study in Suriname.Children (Basel, Switzerland) · 2023Article
- Environmental neurodevelopment toxicity from the perspective of Bronfenbrenner's bioecological model: a case study of toxic metals.Cadernos de saude publica · 2023Article
- Article
- Associations between developmental exposure to environmental contaminants and spatial navigation in late adolescence.New directions for child and adolescent development · 2022Article
- Prenatal metal mixtures and sex-specific infant negative affectivity.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Psychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes.Environment international · 2021Article
- Next Generation Reproductive and Developmental Toxicology: Crosstalk Into the Future.Frontiers in toxicology · 2021Article
- Assessing the relation of chemical and non-chemical stressors with risk-taking related behavior and adaptive individual attributes among adolescents living near the New Bedford Harbor Superfund site.Environment international · 2021Article
- Lineage- and Sex-Dependent Behavioral and Biochemical Transgenerational Consequences of Developmental Exposure to Lead, Prenatal Stress, and Combined Lead and Prenatal Stress in Mice.Environmental health perspectives · 2020Article
- Memory Function, Neurological, and Immunological Biomarkers in Allergic Asthmatic Mice Intratracheally Exposed to Bisphenol A.International journal of environmental research and public health · 2019Article
- Methods for Evaluating the Combined Effects of Chemical and Nonchemical Exposures for Cumulative Environmental Health Risk Assessment.International journal of environmental research and public health · 2018Article
- Potential frameworks to support evaluation of mechanistic data for developmental neurotoxicity outcomes: A symposium report.Neurotoxicology and teratologyArticle
- Associations between a metal mixture and infant negative affectivity: Effect modification by prenatal cortisol and infant sex.Child developmentArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Metals, including lead (Pb), methylmercury (MeHg) and arsenic (As), are long-known developmental neurotoxicants. More recently, environmental context has been recognized to modulate metals toxicity, including nutritional state and stress exposure. Modulation of metal toxicity by stress exposure can occur through shared targeting of endocrine systems, such as the hypothalamic-pituitary-adrenal axis (HPA). Our previous rodent research has identified that prenatal stress (PS) modulates neurotoxicity of two endocrine active metals (EAMs), Pb and MeHg, by altering HPA and CNS systems disrupting behavior. Here, we review this research and further test the hypothesis that prenatal stress modulates metals neurotoxicity by expanding to test the effect of developmental As ± PS exposure. Serum corticosterone and behavior was assessed in offspring of dams exposed to As ± PS. PS increased female offspring serum corticosterone at birth, while developmental As exposure decreased adult serum corticosterone in both sexes. As + PS induced reductions in locomotor activity in females and reduced response rates on a Fixed Interval schedule of reinforcement in males, with the latter suggesting unique learning deficits only in the combined exposure. As-exposed males showed increased time in the open arms of an elevated plus maze and decreased novel object recognition whereas females did not. These data further confirm the hypothesis that combined exposure to chemical (EAMs) and non-chemical (PS) stressors results in enhanced neurobehavioral toxicity. Given that humans are exposed to multiple environmental risk factors that alter endocrine function in development, such models are critical for risk assessment and public health protection, particularly for children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.