ArticleScientific reports2018
Insights into cerebral haemodynamics and oxygenation utilising in vivo mural cell imaging and mathematical modelling.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
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- Postresuscitation Cerebral Vasospasm and Capillary Failure After Experimental Asphyxial Cardiac Arrest.Journal of the American Heart Association · 2026Article
- Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy.Nature biomedical engineering · 2026Article
- Cerebral Resistance Artery Histological Remodeling After Training-Sex Differences.Life (Basel, Switzerland) · 2025Article
- Key Structural Features of Microvascular Networks Leading to the Formation of Multiple Equilibria.Bulletin of mathematical biology · 2025Article
- Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature.Communications biology · 2025Article
- Pericytes in mouse heart.Frontiers in physiology · 2025Article
- Depth-dependent contributions of various vascular zones to cerebral autoregulation and functional hyperemia: An in-silico analysis.PloS one · 2025Article
- Physics-informed deep generative learning for quantitative assessment of the retina.Nature communications · 2024Article
- Modeling oxygen transport in the brain: An efficient coarse-grid approach to capture perivascular gradients in the parenchyma.PLoS computational biology · 2024Article
- Enhanced perfusion following exposure to radiotherapy: A theoretical investigation.PLoS computational biology · 2024Article
- Multi-scale multi-physics model of brain interstitial water flux by transcranial Direct Current Stimulation.Journal of neural engineering · 2023Article
- The post-arteriole transitional zone: a specialized capillary region that regulates blood flow within the CNS microvasculature.The Journal of physiology · 2023Review
- Near-infrared-IIb emitting single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown after traumatic brain injury.Nature communications · 2023Article
- Article
- Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles.Nature communications · 2021Article
- Estimating Increased EGP During Stress Response in Critically Ill Patients.Journal of diabetes science and technology · 2021Article
- Voxelized simulation of cerebral oxygen perfusion elucidates hypoxia in aged mouse cortex.PLoS computational biology · 2021Article
- The pericyte microenvironment during vascular development.Microcirculation (New York, N.Y. : 1994) · 2019Review
- Poster Viewing Sessions PA00-A01 to PA00-A49.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The neurovascular mechanisms underpinning the local regulation of cerebral blood flow (CBF) and oxygen transport remain elusive. In this study we have combined novel in vivo imaging of cortical microvascular and mural cell architecture with mathematical modelling of blood flow and oxygen transport, to provide new insights into CBF regulation that would be inaccessible in a conventional experimental context. Our study indicates that vasoconstriction of smooth muscle actin-covered vessels, rather than pericyte-covered capillaries, induces stable reductions in downstream intravascular capillary and tissue oxygenation. We also propose that seemingly paradoxical observations in the literature around reduced blood velocity in response to arteriolar constrictions might be caused by a propagation of constrictions to upstream penetrating arterioles. We provide support for pericytes acting as signalling conduits for upstream smooth muscle activation, and erythrocyte deformation as a complementary regulatory mechanism. Finally, we caution against the use of blood velocity as a proxy measurement for flow. Our combined imaging-modelling platform complements conventional experimentation allowing cerebrovascular physiology to be probed in unprecedented detail.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.