Evidence map›Paper›PMID 29358931›Full record

ArticleFrontiers in immunology2017

The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8

Jennifer L Hope, Christopher J Stairiker, Panagiota I Spantidea, Donald T Gracias, Alison J Carey, Adam J Fike, Marjan van Meurs, Inge Brouwers-Haspels, Laurine C Rijsbergen, Joseph A Fraietta and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. MicroRNAs in T Cell-Immunotherapy.International journal of molecular sciences · 2022
    Review
  4. Review
  5. Article
  6. MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Non-coding RNAs in CD8 T cell biology.Molecular immunology · 2020
    Review
  17. miR-155 Overexpression in OT-1 CD8Molecular therapy oncolytics · 2020
    Article
  18. MicroRNA-181a regulates IFN-γ expression in effector CD8Journal of molecular medicine (Berlin, Germany) · 2020
    Article
  19. Article
  20. MicroRNA regulation of CD8Non-coding RNA investigation · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Jennifer L HopeDepartment of Immunology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Christopher J StairikerDepartment of Immunology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Panagiota I SpantideaDepartment of Immunology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Donald T GraciasDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Alison J CareyDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Adam J FikeDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Marjan van MeursDepartment of Immunology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Inge Brouwers-HaspelsDepartment of Immunology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Laurine C RijsbergenDepartment of Immunology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Joseph A FraiettaCenter for Cellular Immunotherapies and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, United States.
Yvonne M MuellerDepartment of Immunology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Rosemarieke C KlopDepartment of Immunology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Erietta StelekatiInstitute for Immunology, University of Pennsylvania, Philadelphia, PA, United States.
E John WherryInstitute for Immunology, University of Pennsylvania, Philadelphia, PA, United States.
Stefan J ErkelandDepartment of Immunology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Peter D KatsikisDepartment of Immunology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Erasmus MC · NLDrexel University · USUniversity of Pennsylvania · US

Funding

Virology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ARTHUR Y KIM · 2009 to 2026
$48.1M
Synergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Dario AA Vignali · 2015 to 2026
$30.8M
IMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1M
Sequencing and Viral Evolution CoreU19AI117950 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI RILEY, JAMES L. · 2015 to 2019
$12.0M
Cellular and transcriptional control of exhausted CD8 T cells lineage dynamicsR01AI105343 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WHERRY, E. JOHN · 2014 to 2017
$1.6M
Defining the role of microRNAs in CD8 T cell exhaustionR21AI117718 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WHERRY, E. JOHN · 2015 to 2016
$440k
NCI NIH HHS T32 CA009140NIAID NIH HHS P01 AI108545NIAID NIH HHS R01 AI105343NIAID NIH HHS R21 AI117718NIAID NIH HHS U19 AI082630NIAID NIH HHS U19 AI117950Worldwide Cancer Research 16-1153
6 · The paper itself

Abstract

We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8

Indexed as

CD8+ T cellsinfluenzaMicroRNAsmiR-155Src homology 2-containing inositol phosphatase-1T-bet

Identifiers

PMID29358931
PMCPMC5765282
OpenAlexW2775813249

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.