ReviewWorld journal of diabetes2018
Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment.
Review in World journal of diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 112 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study to Quantify the Autonomic Nervous System Balance in Healthy, Able-Bodied Individuals
Effect of Low-intensity Aerobic Regular Activity on Heart Rate Variability in Type 1 Diabetes
Who cites it
112 citing papers in PubMed, 4 syntheses or guidelines pooled it, 234 citations in OpenAlex.
- Increased fall risk in people with type 2 diabetes and cardiovascular disease: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Pooled it
- Reactive Hyperemia and Cardiovascular Autonomic Neuropathy in Type 2 Diabetic Patients: A Systematic Review of Randomized and Nonrandomized Clinical Trials.Medicina (Kaunas, Lithuania) · 2023Pooled it
- The prevalence of cardiac autonomic neuropathy in prediabetes: a systematic review.Diabetologia · 2021Pooled it
- Effect of exercise training on heart rate variability in type 2 diabetes mellitus patients: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis.Journal of neurology · 2020Trial
- Heart rate variability in adolescents with type 1 diabetes. A cross-sectional study.Acta diabetologica · 2026Article
- Autonomic and neural responses to varying transcutaneous cervical electrical stimulation parameters.Bioelectronic medicine · 2026Article
- Article
- Age-specific associations between blood pressure and cardiovascular disease, kidney disease, and death among individuals with type 2 diabetes: a population-based cohort study.Cardiovascular diabetology · 2026Article
- Cardiac autonomic neuropathy in patients with SGA-treated schizophrenia: a randomized controlled trial of 30 weeks' treatment with semaglutide.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Autonomic Nervous System Dysfunction in Diabetic Patients After Myocardial Infarction: Prognostic Role of the Valsalva Maneuver.Medicina (Kaunas, Lithuania) · 2026Article
- Atherosclerosis Progression in Native Coronaries After Coronary Artery Bypass Grafting: A State-of-the-Art Review.Journal of lipid and atherosclerosis · 2026Review
- Paeoniflorin as a candidate disease-modifying therapy for diabetic peripheral neuropathy: mechanisms, exposure challenges, and translational priorities.Frontiers in pharmacology · 2026Review
- Development and validation of a nomogram model for predicting cardiac autonomic neuropathy in patients with diabetes.Frontiers in endocrinology · 2026Article
- Integrating physical healthcare into psychiatry for severe mental illness: A narrative review and position statement from the ECNP PAN-Health group.Neuroscience applied · 2026Review
- Reduced heart rate variability predicts incident diabetic polyneuropathy.Frontiers in endocrinology · 2026Article
- Role of social determinants, lifestyle and clinical factors in the development of diabetic peripheral neuropathy among a multiethnic Asian population in Singapore: a retrospective analysis.BMJ public health · 2026Article
- Circular RNAs as Biomarkers and Therapeutic Targets in Diabetic Cardiovascular Complications.Endocrinology, diabetes & metabolism · 2026Review
- Recent Advances in the Study of Diabetic Cardiac Autonomic Neuropathy.Reviews in cardiovascular medicine · 2026Review
- Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac autonomic neuropathy (CAN) is a serious complication of diabetes mellitus (DM) that is strongly associated with approximately five-fold increased risk of cardiovascular mortality. CAN manifests in a spectrum of things, ranging from resting tachycardia and fixed heart rate (HR) to development of "silent" myocardial infarction. Clinical correlates or risk markers for CAN are age, DM duration, glycemic control, hypertension, and dyslipidemia (DLP), development of other microvascular complications. Established risk factors for CAN are poor glycemic control in type 1 DM and a combination of hypertension, DLP, obesity, and unsatisfactory glycemic control in type 2 DM. Symptomatic manifestations of CAN include sinus tachycardia, exercise intolerance, orthostatic hypotension (OH), abnormal blood pressure (BP) regulation, dizziness, presyncope and syncope, intraoperative cardiovascular instability, asymptomatic myocardial ischemia and infarction. Methods of CAN assessment in clinical practice include assessment of symptoms and signs,
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.