Evidence map›Paper›PMID 29391383›Full record

Trial reportBMJ open2018

Feasibility study to assess the impact of a lifestyle intervention ('LivingWELL') in people having an assessment of their family history of colorectal or breast cancer.

Annie S Anderson, Jacqueline Dunlop, Stephanie Gallant, Maureen Macleod, Zosia Miedzybrodzka, Nanette Mutrie, Ronan E O'Carroll, Martine Stead, Robert J C Steele, Rod S Taylor and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  11. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Annie S AndersonCentre for Research into Cancer Prevention and Screening / Tayside Cancer Centre, Division of Cancer Research, University of Dundee, Ninewells Hospital & Medical School, Dundee, UK.
Jacqueline DunlopDepartment of Clinical Genetics, Ninewells Hospital and Medical School, Dundee, UK.
Stephanie GallantCentre for Research into Cancer Prevention and Screening / Tayside Cancer Centre, Division of Cancer Research, University of Dundee, Ninewells Hospital & Medical School, Dundee, UK.
Maureen MacleodCentre for Research into Cancer Prevention and Screening / Tayside Cancer Centre, Division of Cancer Research, University of Dundee, Ninewells Hospital & Medical School, Dundee, UK.
Zosia MiedzybrodzkaClinical Genetics Service, Ashgrove House, Foresterhill, Aberdeen, UK.
Nanette MutriePhysical Activity for Health Research Centre, Institute for Sport, Physical Education and Health Sciences, University of Edinburgh, Edinburgh, UK.
Ronan E O'CarrollDivision of Psychology, School of Natural Sciences, University of Stirling, Stirling, UK.
Martine SteadInstitute for Social Marketing, Institute for Social Marketing, University of Stirling, Stirling, UK.
Robert J C SteeleCentre for Research into Cancer Prevention and Screening / Tayside Cancer Centre, Division of Cancer Research, University of Dundee, Ninewells Hospital & Medical School, Dundee, UK.
Rod S TaylorInstitute of Health Research, University of Exeter Medical School, Exeter, UK.
Sarah VinnicombeCentre for Research into Cancer Prevention and Screening / Tayside Cancer Centre, Division of Cancer Research, University of Dundee, Ninewells Hospital & Medical School, Dundee, UK.
Jonathan BergDepartment of Genetic Medicine, Ninewells Hospital and Medical School, Dundee, UK.

Funding

Chief Scientist Office CZH/4/1080
6 · The paper itself

Abstract

objectivesTo assess the feasibility of delivering and evaluating a weight management (WM) programme for overweight patients with a family history (FH) of breast cancer (BC) or colorectal cancer (CRC). STUDY

designA two-arm (intervention vs usual care) randomised controlled trial.

settingNational Health Service (NHS) Tayside and NHS Grampian.

participantsPeople with a FH of BC or CRC aged≥18 years and body mass index of ≥25 kg/m

interventionParticipants were randomised to a control (lifestyle booklet) or 12-week intervention arm where they were given one face-to-face counselling session, four telephone consultations and web-based support. A goal of 5% reduction in body weight was set, and a personalised diet and physical activity (PA) programme was provided. Behavioural change techniques (motivational interviewing, action and coping plans and implementation intentions) were used. PRIMARY OUTCOME: Feasibility measures: recruitment, programme implementation, fidelity measures, achieved measurements and retention, participant satisfaction assessed by questionnaire and qualitative interviews. SECONDARY OUTCOMES: Measured changes in weight and PA and reported diet and psychosocial measures between baseline and 12-week follow-up.

resultsOf 480 patients approached, 196 (41%) expressed interest in the study, and of those, 78 (40%) patients were randomised. Implementation of the programme was challenging within the time allotted and fidelity to the intervention modest (62%). Qualitative findings indicated the programme was well received. Questionnaires and anthropometric data were completed by >98%. Accelerometer data were attained by 84% and 54% at baseline and follow-up, respectively. Retention at 12 weeks was 76%. Overall, 36% of the intervention group (vs 0% in control) achieved 5% weight loss. Favourable increases in PA and reduction in dietary fat were also reported.

conclusionsA lifestyle programme for people with a family history of cancer is feasible to conduct and acceptable to participants, and indicative results suggest favourable outcomes. TRIAL REGISTRATION NUMBER: ISRCTN13123470; Pre-results.

Indexed as

Risk Reduction BehaviorAdultAgedBreast NeoplasmsColorectal NeoplasmsDirective CounselingEarly Detection of CancerEvaluation Studies as TopicFeasibility StudiesFemaleGenetic Predisposition to DiseaseGenetic TestingHumansMaleMiddle AgedYoung Adultcancer geneticsnutritional supportpreventive medicinepublic health

Identifiers

PMID29391383
PMCPMC5879797

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.