ArticleScientific reports2018
Expression analysis of candidate genes for fatty acid composition in adipose tissue and identification of regulatory regions.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 99 citations in OpenAlex.
- Culture Optimization of the IPEC-J2 Piglet Jejunum Cell Line for Applications in Infant Nutrition Research.Molecular nutrition & food research · 2026Article
- Transcription factors and candidate functional SNPs associated with variation in fatty acid composition from skeletal muscle of pigs.Animal genetics · 2025Article
- Unraveling the genetic and epigenetic landscape governing intramuscular fat deposition in rabbits: Insights and implications.Food chemistry. Molecular sciences · 2024Review
- Expression genome-wide association study identifies key regulatory variants enriched with metabolic and immune functions in four porcine tissues.BMC genomics · 2024Article
- Article
- Genome-wide detection of CNV regions between Anqing six-end-white and Duroc pigs.Molecular cytogenetics · 2023Article
- Expression analysis of porcine miR-33a/b in liver, adipose tissue and muscle and its potential role in fatty acid metabolism.PloS one · 2021Article
- Genome-wide identification of m6A-associated functional SNPs as potential functional variants for thyroid cancer.American journal of cancer research · 2021Article
- Identification of strong candidate genes for backfat and intramuscular fatty acid composition in three crosses based on the Iberian pig.Scientific reports · 2020Article
- Identification of eQTLs associated with lipid metabolism in Longissimus dorsi muscle of pigs with different genetic backgrounds.Scientific reports · 2020Article
- Genome-wide association study for carcass quality traits and growth in purebred and crossbred pigs1.Journal of animal science · 2020Article
- Machine learning applied to transcriptomic data to identify genes associated with feed efficiency in pigs.Genetics, selection, evolution : GSE · 2019Article
- A polymorphism in the fatty acid desaturase-2 gene is associated with the arachidonic acid metabolism in pigs.Scientific reports · 2018Article
- Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this work was to study the genetic basis of the backfat expression of lipid-related genes associated with meat quality traits in pigs. We performed a genome-wide association study with the backfat gene expression measured in 44 genes by qPCR and the PorcineSNP60 BeadChip genotypes in 115 Iberian x Landrace backcross animals. A total of 193 expression-associated SNPs located in 19 chromosomal regions were associated with expression levels of ACSM5, ELOVL6, FABP4, FADS2, and SLC27A4 genes. Three expression quantitative trail loci (eQTLs) corresponding to ACSM5, FABP4, and FADS2 were classified as cis-acting eQTLs, whereas the remaining 16 eQTLs have trans-regulatory effects. Remarkably, a SNP in the ACSM5 promoter region and a SNP in the 3'UTR region of FABP4 were the most associated polymorphisms with the ACSM5 and FABP4 expression levels, respectively. Moreover, relevant lipid-related genes mapped in the trans-eQTLs regions associated with the ACSM5, FABP4, FADS2, and SLC27A4 genes. Interestingly, a trans-eQTL hotspot on SSC13 regulating the gene expression of ELOVL6, ELOLV5, and SCD, three important genes implicated in the elongation and desaturation of fatty acids, was identified. These findings provide new data to further understand the functional regulatory mechanisms implicated in the variation of fatty acid composition in pigs.
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