ReviewNature reviews. Endocrinology2018
Symptoms of menopause - global prevalence, physiology and implications.
Review in Nature reviews. Endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 296 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of High Intensity Resistance Training in Postmenopausal Women
Citalopram Improves Vasomotor and Urogenital Syndromes in Mexican Patients With Post-menopause
Comparative Effects of Clinical Pilates Training and Aerobic Exercise on Menopausal Symptoms, Quality of Life, Sleep and Depression
Efficacy of Nano-Pso Therapy Compared to Placebo in the Control of Vasomotor Symptomatology in Early Menopause
Copenhagen Menopause Study (COMPASS): A Randomized Clinical Trial
Who cites it
296 citing papers in PubMed, 12 syntheses or guidelines pooled it.
- Dietary Intake of Animal and Plant-Based Protein on Adiposity Measurements and Body Composition in Pre- and Postmenopausal Women: A Systematic Review of Randomized Clinical Trials.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Pooled it
- The effectiveness of psychosocial interventions on physiological symptoms of menopause: a systematic review and meta-analysis.BMC women's health · 2026Pooled it
- Optimal doses of different exercise types for improving depressive symptoms in climacteric women: a systematic review and network meta-analysis.Frontiers in psychology · 2026Pooled it
- The Effect of Evening Primrose Oil on Menopausal Symptoms Management: A Systematic Review and Meta-Analysis.Journal of caring sciences · 2025Pooled it
- Safety of Fezolinetant for Treatment of Moderate to Severe Vasomotor Symptoms Due to Menopause: Pooled Analysis of Three Randomized Phase 3 Studies.Advances in therapy · 2025Pooled it
- Mind-body therapies for sleep disturbances, depression, and anxiety in menopausal women: a systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2025Pooled it
- Mapping global prevalence of menopausal symptoms among middle-aged women: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Prevalence and associated factors of depression in postmenopausal women: a systematic review and meta-analysis.BMC psychiatry · 2024Pooled it
- Effects of melatonin intake on depression and anxiety in postmenopausal women: a systematic review and meta-analysis of randomised controlled trials.Archives of women's mental health · 2024Pooled it
- A systematic review of community pharmacy interventions to improve peri- and post-menopausal health.Post reproductive health · 2024Pooled it
- Systematic review and meta-analysis of the effects of menopause hormone therapy on cognition.Frontiers in endocrinology · 2024Pooled it
- Effectiveness and safety of East Asian herbal medicine for menopausal insomnia: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Effectiveness of face-to-face and web-based exercise programs on health outcomes in early postmenopausal women: a randomized trial.BMC women's health · 2026Trial
- Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study.PLoS medicine · 2024Trial
- Caffeine optimizes Zumba training benefits on functional performances in middle-aged women: a randomized trial study.Scientific reports · 2024Trial
- Effects of Plant Meristem-Cell-Based Cosmetics on Menopausal Skin: Clinical Data and Mechanisms.Biomolecules · 2024Trial
- Dual-task training is as effective as functional training on the functional fitness of older women: a randomized clinical trial.BMC geriatrics · 2024Trial
- Effects of stellate ganglion block on perimenopausal hot flashes: a randomized controlled trial.Frontiers in endocrinology · 2023Trial
- Sleep Disruption in the Menopausal Transition and Postmenopause: A Narrative Review.Obstetrics and gynecology · 2026Article
- Menopause and skin.Menopause (New York, N.Y.) · 2026Article
236 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The symptoms of menopause can be distressing, particularly as they occur at a time when women have important roles in society, within the family and at the workplace. Hormonal changes that begin during the menopausal transition affect many biological systems. Accordingly, the signs and symptoms of menopause include central nervous system-related disorders; metabolic, weight, cardiovascular and musculoskeletal changes; urogenital and skin atrophy; and sexual dysfunction. The physiological basis of these manifestations is emerging as complex and related, but not limited to, oestrogen deprivation. Findings generated mainly from longitudinal population studies have shown that ethnic, geographical and individual factors affect symptom prevalence and severity. Moreover, and of great importance to clinical practice, the latest research has highlighted how certain menopausal symptoms can be associated with the onset of other disorders and might therefore serve as predictors of future health risks in postmenopausal women. The goal of this Review is to describe in a timely manner new research findings on the global prevalence and physiology of menopausal symptoms and their impact on future health.
Indexed as
Identifiers
29393299What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.