Evidence map›Paper›PMID 29400439›Full record

ReviewACS chemical neuroscience2018

Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System.

Shana M Augustin, David M Lovinger

Open access · greenAbstract readReview
In one paragraph

Review in ACS chemical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 98 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. The Retinal Light Response Is Modulated by an mGluR5-Mediated Retrograde Signal from ON-Bipolar Cells to Photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Ageing, Neurodegeneration and the Endocannabinoid System.Current topics in behavioral neurosciences · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Striatonigral direct pathway 2-arachidonoylglycerol contributes to ethanol effects on synaptic transmission and behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shana M AugustinLaboratory for Integrative Neuroscience , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Rockville , Maryland 20852 , United States.ORCID 0000-0002-8123-8410
David M LovingerLaboratory for Integrative Neuroscience , National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , Rockville , Maryland 20852 , United States.
National Institutes of Health · US

Funding

Synaptic Transmission: Modulation, Plasticity And Effects Of Drugs Of AbuseZIAAA000407 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LOVINGER, DAVID M · 2009 to 2025
$29.6M
Corticostriatal mechanisms of action learning and habit formationZIAAA000416 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LOVINGER, DAVID M · 2009 to 2025
$25.2M
Synaptic Transmission: Modulation, Plasticity And Effects Of Drugs Of AbuseZ01AA000407 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LOVINGER, DAVID M · 2002 to 2008
$3.6M
Intramural NIH HHS Z01 AA000407Intramural NIH HHS ZIA AA000416
6 · The paper itself

Abstract

The endocannabinoid (eCB) signaling system plays a key role in short-term and long-term synaptic plasticity in brain regions involved in various neural functions ranging from action selection to appetite control. This review will explore the role of eCBs in shaping neural circuit function to regulate behaviors. In particular, we will discuss the behavioral consequences of eCB mediated long-term synaptic plasticity in different brain regions. This review brings together evidence from in vitro and ex vivo studies and points out the need for more in vivo studies.

Indexed as

Neuronal PlasticityAmygdalaAnimalsArachidonic AcidsBehavior, AddictiveBrainCerebellumCerebral CortexConditioning, PsychologicalCorpus StriatumEndocannabinoidsExtinction, PsychologicalFearGlyceridesGoalsHippocampusanandamideArachidonic AcidsEndocannabinoidsGlyceridesglyceryl 2-arachidonatePolyunsaturated AlkamidesReceptors, Cannabinoid2-arachidonoylglycerolArachidonoylethanolaminecannabinoid receptorsdepolarization-induced suppression of excitationdepolarization-induced suppression of inhibitionlong-term depressionlong-term potentiation

Identifiers

PMID29400439
PMCPMC6720113
OpenAlexW2787095062

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.