ArticlePsychopharmacology2018
Intravenous cocaine self-administration in a panel of inbred mouse strains differing in acute locomotor sensitivity to cocaine.
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Variation in cocaine responses across genetically diverse mouse strains.Psychopharmacology · 2026Article
- Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations.Psychopharmacology · 2026Article
- Intranasal cocaine self-administration in male mice.Nature communications · 2025Article
- Impaired extinction of operant cocaine in a genetic mouse model of schizophrenia risk.Psychopharmacology · 2023Article
- Microbial glutamate metabolism predicts intravenous cocaine self-administration in diversity outbred mice.Neuropharmacology · 2023Article
- Sex Differences in Cocaine Sensitization Vary by Mouse Strain.Neuroendocrinology · 2023Article
- Extreme phenotypic diversity in operant response to intravenous cocaine or saline infusion in the hybrid mouse diversity panel.Addiction biology · 2022Article
- The collaborative cross strains and their founders vary widely in cocaine-induced behavioral sensitization.Frontiers in behavioral neuroscience · 2022Article
- BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity.Biomolecules · 2021Review
- Spontaneously Hypertensive Rat substrains show differences in model traits for addiction risk and cocaine self-administration: Implications for a novel rat reduced complexity cross.Behavioural brain research · 2021Article
- Methodological and analytical issues of progressive ratio schedules: Definition and scaling of breakpoint.Journal of neuroscience methods · 2021Article
- Pharmacokinetic and pharmacodynamic analyses of cocaine and its metabolites in behaviorally divergent inbred mouse strains.Genes, brain, and behavior · 2021Article
- What Have We Learned (or Expect to) From Analysis of Murine Genetic Models Related to Substance Use Disorders?Frontiers in psychiatry · 2021Review
- Characterization of genetically complex Collaborative Cross mouse strains that model divergent locomotor activating and reinforcing properties of cocaine.Psychopharmacology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleInitial sensitivity to drugs of abuse often predicts subsequent use and abuse, but this relationship is not always observed in human studies. Moreover, studies examining the relationship between initial locomotor sensitivity and the rewarding and reinforcing effects of drugs in animal models have also been equivocal. Understanding the relationship between initial drug effects and propensity to continue use, potentially resulting in the development of a substance use disorder, may help to identify key targets for prevention and treatment.
objectivesWe examined intravenous cocaine self-administration in a set of mouse strains that were previously identified to be at the phenotypic extremes for cocaine-induced locomotor activation to determine if initial locomotor sensitivity predicted acquisition, extinction, dose response, or progressive ratio (PR) breakpoint.
methodsWe selected eight inbred mouse strains based on locomotor sensitivity to 20 mg/kg cocaine. These strains, designated as low and high responders, were tested in an intravenous self-administration paradigm that included acquisition of 0.5 mg/(kg*inf) under a FR1 schedule, extinction, re-acquisition, dose response to 0.125, 0.25, 0.5, 1, and 2 mg/(kg*inf), and progressive ratio.
resultsWe observed overall differences in self-administration behavior between high and low responders. Low responders self-administered less cocaine and had lower breakpoints under the PR schedule. However, we also observed strain differences within each group. Self-administration in the low responder, LG/J, more closely resembled the behavior of the high-responding group, and the high responder, P/J, had self-administration behavior that more closely resembled the low-responding group.
conclusionsWe conclude that acute cocaine-induced locomotor activation does predict self-administration behavior, but in a strain-specific manner. These data support the idea that genetic background influences the relationship among addiction-related behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.