Evidence mapPaperPMID 29427336Full record

ArticleResearch synthesis methods2018

Bayesian multivariate meta-analysis of multiple factors.

Lifeng Lin, Haitao Chu

Abstract read
In one paragraph

Article in Research synthesis methods, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 6 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Bayesian Methods for Meta-Analyses of Binary Outcomes: Implementations, Examples, and Impact of Priors.International journal of environmental research and public health · 2021
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lifeng LinDepartment of Statistics, Florida State University, Tallahassee, FL, 32306, USA.ORCID http://orcid.org/0000-0002-3562-9816
Haitao ChuDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA.ORCID http://orcid.org/0000-0003-0932-598X

Funding

Transplant Biology and TherapyP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · 1998 to 2025
$35.0M
NCI NIH HHS P30 CA077598NIAID NIH HHS R21 AI103012NIDCR NIH HHS R03 DE024750NIDDK NIH HHS U01 DK106786NIMHD NIH HHS U54 MD008620NLM NIH HHS R21 LM012197NLM NIH HHS R21 LM012744
6 · The paper itself

Abstract

In medical sciences, a disease condition is typically associated with multiple risk and protective factors. Although many studies report results of multiple factors, nearly all meta-analyses separately synthesize the association between each factor and the disease condition of interest. The collected studies usually report different subsets of factors, and the results from separate analyses on multiple factors may not be comparable because each analysis may use different subpopulation. This may impact on selecting most important factors to design a multifactor intervention program. This article proposes a new concept, multivariate meta-analysis of multiple factors (MVMA-MF), to synthesize all available factors simultaneously. By borrowing information across factors, MVMA-MF can improve statistical efficiency and reduce biases compared with separate analyses when factors were missing not at random. As within-study correlations between factors are commonly unavailable from published articles, we use a Bayesian hybrid model to perform MVMA-MF, which effectively accounts for both within- and between-study correlations. The performance of MVMA-MF and the conventional methods are compared using simulations and an application to a pterygium dataset consisting of 29 studies on 8 risk factors.

Indexed as

Meta-Analysis as TopicMultivariate AnalysisBayes TheoremComputer SimulationData Interpretation, StatisticalHumansModels, StatisticalOdds RatioOutcome Assessment, Health CareProbabilityPterygiumRegression AnalysisRisk FactorsBayesian hybrid modelmissing datamultiple factorsmultivariate meta-analysiswithin-study correlation

Identifiers

PMID29427336
PMCPMC5988916

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.