ArticleJournal of diabetes investigation2018
Analysis of pancreatic volume in acute-onset, slowly-progressive and fulminant type 1 diabetes in a Japanese population.
Article in Journal of diabetes investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Large-scale multi-center CT and MRI segmentation of pancreas with deep learning.Medical image analysis · 2025Article
- Cross-sectional imaging of the pancreas in diabetes.Abdominal radiology (New York) · 2024Review
- Distinct changes to pancreatic volume rather than pancreatic autoantibody positivity: insights into immune checkpoint inhibitors induced diabetes mellitus.Diabetology & metabolic syndrome · 2024Article
- Pancreas Imaging of Children with Type 1 Diabetes Reveals New Patterns and Correlations with Pancreatic Functions.Pediatric diabetes · 2023Article
- Type 1 Diabetes: A Disorder of the Exocrine and Endocrine Pancreas.Journal of cellular immunology · 2023Article
- Pancreatic involvement in celiac disease.World journal of gastroenterology · 2022Review
- Imaging evaluation of the pancreas in diabetic patients.Abdominal radiology (New York) · 2022Review
- Serum trypsin-like immunoreactivity in dogs with diabetes mellitus.Journal of veterinary internal medicine · 2021Article
- Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size.Diabetes · 2021Article
- Pancreatic fat accumulation evaluated by multidetector computed tomography in patients with type 2 diabetes.Journal of diabetes investigation · 2020Article
- Pleiotropic roles of the insulin-like growth factor axis in type 1 diabetes.Current opinion in endocrinology, diabetes, and obesity · 2019Review
- Structure and function of the exocrine pancreas in patients with type 1 diabetes.Reviews in endocrine & metabolic disorders · 2019Review
- Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes.Diabetes care · 2019Article
- Slowly Progressive Type 1 Diabetes Mellitus: Current Knowledge And Future Perspectives.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Review
- Analysis of pancreatic volume in acute-onset, slowly-progressive and fulminant type 1 diabetes in a Japanese population.Journal of diabetes investigation · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS/
introductionA decrease in the size of the pancreas is observed in islet autoantibody-positive non-diabetic donors and acute-onset type 1 diabetes irrespective of the diabetes duration. Little is known, however, about the relationship between the size of the pancreas and type 1 diabetes subtypes, including fulminant type 1 diabetes. MATERIALS AND
methodsWe examined the pancreatic volume (PV) in 44 adult patients with type 1 diabetes (16 acute-onset type 1 diabetes, 18 slowly progressive type 1 diabetes and 10 fulminant type 1 diabetes) and 39 age- and body mass index-matched non-diabetic controls. PV was measured by computed tomography. The ability to secrete insulin was assessed by stimulated C-peptide after intravenous glucagon administration.
resultsPV was significantly correlated with bodyweight in both control participants and type 1 diabetes patients. The PV index (PVI; PV/bodyweight) was decreased by 39% in type 1 diabetes compared with that in controls. PVI was significantly decreased in acute-onset type 1 diabetes patients and slowly progressive type 1 diabetes patients (both P < 0.0001), but not in fulminant type 1 diabetes patients (P = 0.10), compared with control participants. In cases patients with recent-onset type 1 diabetes (0-7 days post-diagnosis), PVI was significantly decreased in acute-onset type 1 diabetes patients (n = 8, P = 0.0005), but not in fulminant type 1 diabetes patients (n = 7, P = 0.44), compared with controls. PVI showed no correlations with the diabetes duration, C-peptide levels, glycated hemoglobin, glutamic acid decarboxylase autoantibody levels, serum amylase or daily total insulin dose in type 1 diabetes subtypes.
conclusionsThe present results show that patients with acute-onset type 1 diabetes and slowly progressive type 1 diabetes have small pancreases irrespective of the diabetes duration or C-peptide levels. In contrast to earlier findings on acute-onset type 1 diabetes, we found no reduction of PVI at the onset of fulminant type 1 diabetes.
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