Evidence map›Paper›PMID 29437928›Full record

ArticlemBio2018

Exploring the Antimicrobial Action of Quaternary Amines against

Gregory A Knauf, Ashley L Cunningham, Misha I Kazi, Ian M Riddington, Alexander A Crofts, Vincent Cattoir, M Stephen Trent, Bryan W Davies

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 59 citations in OpenAlex.

  1. Trial
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  7. Article
  8. Drug Repurposing: An Emerging Strategy inJournal of microbiology and biotechnology · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Drug Repositioning as a Therapeutic Strategy againstInternational journal of molecular sciences · 2023
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Gregory A KnaufDepartment of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA.
Ashley L CunninghamDepartment of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA.
Misha I KaziDepartment of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA.
Ian M RiddingtonDepartment of Chemistry, University of Texas at Austin, Austin, Texas, USA.
Alexander A CroftsDepartment of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA.
Vincent CattoirUniversity of Rennes 1, Inserm Unit U1230, Rennes, France.
M Stephen TrentDepartment of Infectious Diseases, University of Georgia, College of Veterinary Medicine, Athens, Georgia, USA.
Bryan W DaviesDepartment of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA bwdavies@utexas.edu.
The University of Texas at Austin · USGeorgia College & State University · USInserm · FR

Funding

MODIFICATION OF HELICOBACTER PYLORI LIPOPOLYSACCHARIDESR01AI064184 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI TRENT, MICHAEL STEPHEN · 2006 to 2015
$3.4M
The Outer Surface of Vibrio CholeraeR01AI076322 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI TRENT, MICHAEL STEPHEN · 2008 to 2017
$3.2M
A High-Throughput Molecular Platform for Antimicrobial Discovery and StudyR01AI125337 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI DAVIES, BRYAN WILLIAM · 2016 to 2020
$2.0M
The Outer Surface of Vibrio choleraeR56AI076322 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI TRENT, MICHAEL STEPHEN · 2013 to 2013
$384k
NIAID NIH HHS R01 AI064184NIAID NIH HHS R01 AI076322NIAID NIH HHS R01 AI125337NIAID NIH HHS R56 AI076322
6 · The paper itself

Abstract

Quaternary amine compounds (QAC) are potent antimicrobials used to prevent the spread of pathogenic bacteria. While they are known for their membrane-damaging properties, QAC action has been suggested to extend beyond the surface to intracellular targets. Here we characterize the range of action of the QAC biocide benzalkonium chloride (BZK) against the bacterial pathogen

Indexed as

Protein AggregatesAcinetobacter baumanniiAnti-Bacterial AgentsBacterial ProteinsBenzalkonium CompoundsCell MembraneClostridioides difficileMicrobial ViabilityStaphylococcus aureusAnti-Bacterial AgentsBacterial ProteinsBenzalkonium CompoundsProtein AggregatesAcinetobacter baumanniiantimicrobialbenzalkonium chloridebiocideBZKclostridiumproteostasisquaternary amine

Identifiers

PMID29437928
PMCPMC5801471
OpenAlexW2786435729

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.