Evidence map›Paper›PMID 29445381›Full record

ArticleFrontiers in immunology2018

Proteins of TNF-α and IL6 Pathways Are Elevated in Serum of Type-1 Diabetes Patients with Microalbuminuria.

Sharad Purohit, Ashok Sharma, Wenbo Zhi, Shan Bai, Diane Hopkins, Leigh Steed, Bruce Bode, Stephen W Anderson, John Chip Reed, R Dennis Steed and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Goutweed (Molecules (Basel, Switzerland) · 2025
    Review
  5. Review
  6. Albuminuria and Serum Tumor Necrosis Factor Receptor Levels in Patients with Type 2 Diabetes on SGLT2 Inhibitors: A Prospective Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. T1DMicro: A Clinical Risk Calculator for Type 1 Diabetes Related Microvascular Complications.International journal of environmental research and public health · 2021
    Article
  13. Article
  14. Review
  15. Article
  16. Plants as Sources of Anti-Inflammatory Agents.Molecules (Basel, Switzerland) · 2020
    Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Sharad PurohitCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA, United States.
Ashok SharmaCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA, United States.
Wenbo ZhiCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA, United States.
Shan BaiCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA, United States.
Diane HopkinsCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA, United States.
Leigh SteedCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA, United States.
Bruce BodeAtlanta Diabetes Associates, Atlanta, GA, United States.
Stephen W AndersonPediatric Endocrine Associates, Atlanta, GA, United States.
John Chip ReedSoutheastern Endocrine & Diabetes, Atlanta, GA, United States.
R Dennis SteedSoutheastern Endocrine & Diabetes, Atlanta, GA, United States.
Jin-Xiong SheCenter for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA, United States.
Augusta University Health · USDiabetes & Endocrine Associates · USAugusta University · USAtlanta Diabetes Associates · US

Funding

Studies of the Immunopathogenesis of Type 1 DiabetesR01HD037800 · NICHD · UNIVERSITY OF FLORIDA · PI SHE, JIN-XIONG · 1999 to 2006
$4.6M
Proteomic changes/progression of human type 1 diabetesR33HD050196 · NICHD · AUGUSTA UNIVERSITY · PI SHE, JIN-XIONG · 2006 to 2008
$1.5M
Proteomic changes/progression of human type 1 diabetesR21HD050196 · NICHD · MEDICAL COLLEGE OF GEORGIA (MCG) · PI SHE, JIN-XIONG · 2004 to 2005
$715k
NICHD NIH HHS R01 HD037800NICHD NIH HHS R21 HD050196NICHD NIH HHS R33 HD050196
6 · The paper itself

Abstract

Soluble cytokine receptors may play an important role in development of microalbuminuria (MA) in type-1 diabetes (T1D). In this study, we measured 12 soluble receptors and ligands from TNF-α/IL6/IL2 pathways in T1D patients with MA (

Indexed as

AdultAgedAlbuminuriaBiomarkersBlood ProteinsDiabetes Mellitus, Type 1FemaleHumansInflammationInterleukin-6MaleMiddle AgedOdds RatioReceptors, CytokineReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIBiomarkersBlood ProteinsIL6 protein, humanInterleukin-6Receptors, CytokineReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IITumor Necrosis Factor-alphacytokine receptorscytokinesdiabetesinflammationmicroalbuminuria

Identifiers

PMID29445381
PMCPMC5797770
OpenAlexW2791918159

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.