Evidence map›Paper›PMID 29446544›Full record

ArticleJournal of diabetes2018

Association between plasma trans-fatty acid concentrations and diabetes in a nationally representative sample of US adults.

Buyun Liu, Yangbo Sun, Linda G Snetselaar, Qi Sun, Quanhe Yang, Zefeng Zhang, Liegang Liu, Frank B Hu, Wei Bao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Buyun LiuDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.
Yangbo SunDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.
Linda G SnetselaarDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.
Qi SunDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Quanhe YangDivision for Heart Disease and Stroke Prevention, National Center for Chronic Disease and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Zefeng ZhangDivision for Heart Disease and Stroke Prevention, National Center for Chronic Disease and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Liegang LiuDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frank B HuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Wei BaoDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.ORCID http://orcid.org/0000-0002-7301-5786
University of Iowa · USBrigham and Women's Hospital · USCenters for Disease Control and Prevention · USMinistry of Health · TO

Funding

Pulmonary Toxicology FacilityP30ES005605 · UNIVERSITY OF IOWA · 1990 to 2025
$8.8M
NICHD NIH HHS R21 HD091458NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

backgroundA diet high in trans-fatty acids (TFA) induces insulin resistance in rodent models and primates. However, previous epidemiological studies on the association between TFAs, based primarily on self-reported intake from the diet, and diabetes in humans have yielded conflicting results. Herein we examined the associations of objectively measured plasma TFA concentrations with diabetes in a large population-based study among US adults.

methodsWe included 3801 participants aged ≥20 years from the National Health and Nutrition Examination Survey 1999-2000 and 2009-10. Four major TFAs, namely palmitelaidic acid (C16:1 n-7t), elaidic acid (C18:1 n-9t), vaccenic acid (C18:1 n-7t), and linolelaidic acid (C18:2 n-6t, 9t), were measured in fasting plasma using gas chromatography-mass spectrometry. Diabetes was defined by self-reported physician diagnosis, plasma fasting glucose ≥126 mg/dL, or HbA1c ≥6.5%.

resultsAfter adjustment for other major risk factors, the odds ratios (95% confidence intervals) of diabetes comparing the highest with lowest quintile of plasma TFAs was 2.19 (1.27-3.79) for total TFAs (P

conclusionsIn a nationally representative population, plasma TFAs, in particular elaidic acid, were positively associated with diabetes and biomarkers of glucose metabolism.

Indexed as

AdultBlood GlucoseDiabetes MellitusFastingFatty Acids, MonounsaturatedFemaleHumansInsulinInsulin ResistanceLinoleic AcidMaleMiddle AgedNutrition SurveysOleic AcidOleic AcidsRisk Factors11-octadecenoic acidBlood Glucoseelaidic acidFatty Acids, MonounsaturatedInsulinLinoleic AcidOleic AcidOleic Acidspalmitoleic acidTrans Fatty Acidsdiabeteselaidic acidglucose metabolisminsulin resistancetrans-fatty acid反式脂肪酸反油酸、葡萄糖代谢糖尿病胰岛素抵抗

Identifiers

PMID29446544
PMCPMC6093805
OpenAlexW2794221047

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.