Evidence map›Paper›PMID 29449643›Full record

ArticleCell death and differentiation2018

SIRT2 regulates oxidative stress-induced cell death through deacetylation of c-Jun NH

Mohsen Sarikhani, Sneha Mishra, Perumal Arumugam Desingu, Chaithanya Kotyada, Donald Wolfgeher, Mahesh P Gupta, Mahavir Singh, Nagalingam R Sundaresan

Open access · bronzeAbstract read
In one paragraph

Article in Cell death and differentiation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 68 citations in OpenAlex.

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  5. Mechanisms and Therapeutic Potential of Myofibroblast Transformation in Pulmonary Fibrosis.Journal of respiratory biology and translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Mohsen SarikhaniDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Sneha MishraDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Perumal Arumugam DesinguDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Chaithanya KotyadaMolecular Biophysics Unit, Indian Institute of Science, Bengaluru, India.
Donald WolfgeherDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, USA.
Mahesh P GuptaDepartment of Surgery, University of Chicago, Chicago, IL, USA.
Mahavir SinghMolecular Biophysics Unit, Indian Institute of Science, Bengaluru, India.
Nagalingam R SundaresanDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India. rsundaresan@iisc.ac.in.
Indian Institute of Science Bangalore · INUniversity of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

c-Jun NH

Indexed as

ApoptosisOxidative StressAcetaminophenAcetylationAdenosine TriphosphateAnimalsChemical and Drug Induced Liver InjuryCrystallography, X-RayE1A-Associated p300 ProteinHydrogen PeroxideMAP Kinase Kinase 4MiceMice, KnockoutMitogen-Activated Protein Kinase 8Molecular Dynamics SimulationMutagenesis, Site-DirectedAcetaminophenAdenosine TriphosphateE1A-Associated p300 ProteinEp300 protein, mouseHydrogen PeroxideMAP Kinase Kinase 4Mitogen-Activated Protein Kinase 8Sirtuin 2

Identifiers

PMID29449643
PMCPMC6143545
OpenAlexW2790825489

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.