Evidence map›Paper›PMID 29453879›Full record

ReviewTransplant international : official journal of the European Society for Organ Transplantation2018

Defining outcomes for β-cell replacement therapy in the treatment of diabetes: a consensus report on the Igls criteria from the IPITA/EPITA opinion leaders workshop.

Michael R Rickels, Peter G Stock, Eelco J P de Koning, Lorenzo Piemonti, Johann Pratschke, Rodolfo Alejandro, Melena D Bellin, Thierry Berney, Pratik Choudhary, Paul R Johnson and 16 more

Open access · bronzeAbstract readConsensus StatementReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Transplant international : official journal of the European Society for Organ Transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. First world consensus conference on pancreas transplantation: Part I-Methods and results of literature search.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Continuous Glucose Monitoring Before and After Simultaneous Pancreas-Kidney Transplantation: Insights from a Real-World Clinical Setting.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
    Article
  7. Review
  8. Review
  9. One-Year HbA1c Predicts Long-Term Pancreas Graft Survival Following SPK Transplantation: A US Population Cohort Study.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
  10. Comparative Analysis of Islet Auto-Transplantation Outcome Classification Systems: Evaluating Concordance, Feasibility, and a Data-Driven Approach.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Validation of Igls Criteria for Islet Transplant Functional Status Using Person-Reported Outcome Measures in a Cross-Sectional Study.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  16. Chronic Pancreas Allograft Rejection Followed by Successful HLA-Incompatible Islet Alloautotransplantation: A Novel Strategy?Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  17. Review
  18. Metabolic Outcomes After Pancreas Transplant Alone From Donation After Circulatory Death Donors-The UK Transplant Registry Analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  19. Observational
  20. Analyzing outcomes following pancreas transplantation: Definition of a failure or failure of a definition.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 20 institutions in 10 countries.

Michael R RickelsDepartment of Medicine, Division of Endocrinology, Diabetes & Metabolism, Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-9253-838X
Peter G StockDepartment of Surgery, Division of Transplantation, University of California at San Francisco, San Francisco, CA, USA.
Eelco J P de KoningDepartment of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Lorenzo PiemontiDiabetes Research Institute, San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-2172-2198
Johann PratschkeDepartment of Surgery, Charité Medical School, Berlin, Germany.
Rodolfo AlejandroDepartment of Medicine, Division of Endocrinology, Diabetes & Metabolism, Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Melena D BellinDepartment of Pediatrics, Division of Endocrinology, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, USA.
Thierry BerneyDepartment of Surgery, Division of Transplantation and Visceral Surgery, Geneva University Hospital, Geneva, Switzerland.ORCID 0000-0002-4230-9378
Pratik ChoudharyDiabetes Research Group, King's College London, London, UK.
Paul R JohnsonNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Raja KandaswamyDepartment of Surgery, Division of Transplantation, Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, USA.
Thomas W H KayDepartment of Medicine, St. Vincent's Hospital, St. Vincent's Institute of Medical Research, University of Melbourne, Melbourne, Vic., Australia.
Bart KeymeulenDiabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium.
Yogish C KudvaDepartment of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism & Nutrition, Mayo Clinic, Rochester, MN, USA.
Esther LatresJDRF International, New York, NY, USA.
Robert M LangerOrdensklinikum Elisabethinin Hospital, Linz, Austria.
Roger LehmannDepartment of Endocrinology and Diabetology, University Hospital Zurich, Zurich, Switzerland.
Barbara LudwigDepartment of Medicine III, Division of Endocrinology and Diabetes, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
James F MarkmannDepartment of Surgery, Division of Transplantation, Massachusetts General Hospital, Boston, MA, USA.
Marjana MarinacJDRF International, New York, NY, USA.
Jon S OdoricoDepartment of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
François PattouDepartment of General and Endocrine Surgery, Centre Hospitalier Universitaire de Lille, Inserm, Université de Lille, Lille, France.
Peter A SeniorDepartment of Medicine, Division of Endocrinology & Metabolism, University of Alberta, Edmonton, AB, Canada.
James A M ShawInstitute of Transplantation, The Freeman Hospital, Newcastle University, Newcastle upon Tyne, UK.
Marie-Christine VantyghemDepartment of Endocrinology, Diabetology and Metabolism, Centre Hospitalier Universitaire de Lille, Inserm, Université de Lille, Lille, France.
Steven WhiteInstitute of Transplantation, The Freeman Hospital, Newcastle University, Newcastle upon Tyne, UK.
Breakthrough T1D · USFreeman Hospital · GBInserm · FRUniversity of Minnesota · USKing's College London · GBKrankenhaus der Elisabethinen · ATLeiden University Medical Center · NLMassachusetts General Hospital · USMayo Clinic in Arizona · USMSB Medical School Berlin · DESt Vincent's Hospital Melbourne · AUUniversity Hospital Carl Gustav Carus · DEUniversity Hospital of Geneva · CHUniversity Hospital of Zurich · CHUniversity of Alberta · CAUniversity of California, San Francisco · USUniversity of Miami · USUniversity of Oxford · GBUniversity of Pennsylvania · USUniversity of Wisconsin–Madison · US

Funding

Clinical Acceptance of the Artificial Pancreas: the International Diabetes Closed Loop (iDCL) TrialUC4DK108483 · NIDDK · UNIVERSITY OF VIRGINIA · PI ANDERSON, STACEY, DOYLE, FRANCIS J · 2016 to 2016
$12.7M
B-Lymphocyte Immunotherapy in Islet TransplantationU01DK070430 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI NAJI, ALI · 2004 to 2011
$10.1M
Evaluation of the entero-insular (incretin) axis in cystic fibrosis-competitive renewal.R01DK097830 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI KELLY, ANDREA BRIDGET, RICKELS, MICHAEL R · 2012 to 2024
$5.7M
Glucose Counterregulation in Long Standing Type 1 DiabetesR01DK091331 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI RICKELS, MICHAEL R · 2011 to 2020
$3.8M
NIDDK NIH HHS R01 DK091331NIDDK NIH HHS R01 DK097830NIDDK NIH HHS U01 DK070430NIDDK NIH HHS UC4 DK108483
6 · The paper itself

Abstract

β-cell replacement therapy, available currently as pancreas or islet transplantation, has developed without a clear definition of graft functional and clinical outcomes. The International Pancreas & Islet Transplant Association (IPITA) and European Pancreas & Islet Transplantation Association (EPITA) held a workshop to develop consensus for an IPITA/EPITA Statement on the definition of function and failure of current and future forms of β-cell replacement therapy. There was consensus that β-cell replacement therapy could be considered as a treatment for β-cell failure, regardless of etiology and without requiring undetectable C-peptide, accompanied by glycemic instability with either problematic hypoglycemia or hyperglycemia. Glycemic control should be assessed at a minimum by glycated hemoglobin (HbA

Indexed as

Islets of Langerhans TransplantationOutcome Assessment, Health CareBlood GlucoseDiabetes MellitusGlycated HemoglobinHumansBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanislet clinicalOutcomepancreas clinical

Identifiers

PMID29453879
PMCPMC5867272
OpenAlexW2792514710

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.