ArticleDiabetology & metabolic syndrome2018
Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes.
Article in Diabetology & metabolic syndrome, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Cardiorespiratory fitness in individuals with type 2 diabetes mellitus: a systematic review and meta-analysis.Archives of endocrinology and metabolism · 2023Pooled it
- Antioxidants Supplementation During Exercise: Friends or Enemies for Cardiovascular Homeostasis?Journal of cardiovascular translational research · 2023Pooled it
- Vitamin C May Improve Left Ventricular Ejection Fraction: A Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Comprehensive CMR evaluation including 4D flow-derived E/A vorticity ratio in overweight adults with and without type 2 diabetes mellitus.Cardiovascular diabetology · 2025Trial
- Trial
- International Society of Sports Nutrition position stand: effects of dietary antioxidants on exercise and sports performance.Journal of the International Society of Sports Nutrition · 2026Review
- Type 2 diabetes is linked to higher physiologic markers of effort during exercise.Frontiers in clinical diabetes and healthcare · 2024Article
- Glucose Uptake by Skeletal Muscle within the Contexts of Type 2 Diabetes and Exercise: An Integrated Approach.Nutrients · 2022Review
- Single-leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes.The Journal of physiology · 2022Article
- N-Acetyl Cysteine, Selenium, and Ascorbic Acid Rescue Diabetic Cardiac Hypertrophy via Mitochondrial-Associated Redox Regulators.Molecules (Basel, Switzerland) · 2021Article
- Antioxidants and Exercise Performance: With a Focus on Vitamin E and C Supplementation.International journal of environmental research and public health · 2020Review
- Advanced Glycation End Products: Potential Mechanism and Therapeutic Target in Cardiovascular Complications under Diabetes.Oxidative medicine and cellular longevity · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPeople with type 2 diabetes (T2D) have impaired exercise capacity, even in the absence of complications, which is predictive of their increased cardiovascular mortality. Cardiovascular dysfunction is one potential cause of this exercise defect. Acute infusion of vitamin C has been separately shown to improve diastolic and endothelial function in prior studies. We hypothesized that acute vitamin C infusion would improve exercise capacity and that these improvements would be associated with improved cardiovascular function.
methodsAdults with T2D (n = 31, 7 female, 24 male, body mass index (BMI): 31.5 ± 0.8 kg/m
resultsAcute vitamin C infusion improved diastolic function, assessed by lateral and septal E:E' (
conclusionAcute vitamin C infusion improved diastolic function but did not change FMD, forearm reactive hyperemia, or peak exercise capacity. Future studies should further clarify the role of endothelial function as well as other possible physiological causes of exercise impairment in order to provide potential therapeutic targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.