Evidence map›Paper›PMID 29457674›Full record

ReviewThe American journal on addictions2018

A review of brain stimulation methods to treat substance use disorders.

Alexandria S Coles, Karolina Kozak, Tony P George

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in The American journal on addictions, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 77 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 10 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05350033 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Transcranial Direct Current Stimulation on Inhibitory Control in Addictions: a Triple-blinded, Sham-controlled Clinical Trial.

TypeinterventionalSponsorUniversidad de AlmeriaRan2021 to 2022Enrolled200ConditionsSubstance-Related DisordersArmstDCS - tDCS, tDCS - Sham, Sham - tDCS, Sham - Sham
NCT05845164 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Impulsivity Mediation Using Transcranial Direct Current Stimulation Paired With Acceptance Commitment Therapy as an Adjunctive Therapy for Substance Use Disorder

TypeinterventionalSponsorUniversity of ArizonaRan2023 to 2023Enrolled30ConditionsSubstance Use Disorders, Substance Abuse, Substance UseArmstDCS, tDCS Sham
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 10 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Pooled it
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  3. A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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  6. A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2020
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  12. Early efficacy of rTMS intervention at week 2 predicts subsequent responses at week 24 in schizophrenia in a randomized controlled trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alexandria S ColesAddictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.ORCID 0000-0002-7557-8793
Karolina KozakAddictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Tony P GeorgeAddictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.ORCID 0000-0003-1645-9767
Centre for Addiction and Mental Health · CA

Funding

Effects of rTMS on Cannabis Use and Cognitive Outcomes in SchizophreniaR21DA043949 · NIDA · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI GEORGE, TONY P · 2017 to 2018
$286k
CIHR MOP#115145NIDA NIH HHS R21 DA043949
6 · The paper itself

Abstract

backgroundSubstance use disorders (SUDs) are a leading cause of disability worldwide. While several pharmacological and behavioral treatments for SUDs are available, these may not be effective for all patients. Recent studies using non-invasive neuromodulation techniques including Repetitive Transcranial Magnetic Stimulation (rTMS), Transcranial Direct Current Stimulation (tDCS), and Deep Brain Stimulation (DBS) have shown promise for SUD treatment.

objectiveMultiple studies were evaluated investigating the therapeutic potential of non-invasive brain stimulation techniques in treatment of SUDs.

methodThrough literature searches (eg, PubMed, Google Scholar), 60 studies (2000-2017) were identified examining the effect of rTMS, tDCS, or DBS on cravings and consumption of SUDs, including tobacco, alcohol, cannabis, opioids, and stimulants.

resultsrTMS and tDCS demonstrated decreases in drug craving and consumption, while early studies with DBS suggest similar results. Results are most encouraging when stimulation is targeted to the Dorsolateral Prefrontal Cortex (DLPFC).

conclusionsShort-term treatment with rTMS and tDCS may have beneficial effects on drug craving and consumption. Future studies should focus on extending therapeutic benefits by increasing stimulation frequency and duration of treatment. SCIENTIFIC SIGNIFICANCE: The utility of these methods in SUD treatment and prevention are unclear, and warrants further study using randomized, controlled designs. (Am J Addict 2018;27:71-91).

Indexed as

Deep Brain StimulationHumansSubstance-Related DisordersTranscranial Direct Current StimulationTranscranial Magnetic StimulationTreatment OutcomeAlcoholBrain StimulationCannabisDeep Brain Stimulation (DBS)Non-InvasiveOpioidsRepetitive Transcranial Magnetic Stimulation (rTMS)StimulantsTobaccoTranscranial Direct Current Stimulation (tDCS)

Identifiers

PMID29457674
PMCPMC6034717
OpenAlexW2792629465

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.