ArticleBMC genomics2018
Global study of holistic morphological effectors in the budding yeast Saccharomyces cerevisiae.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- HTD1265 Disrupts GimC-Dependent Cellular Processes inPathogens (Basel, Switzerland) · 2026Article
- Systematic data analysis pipeline for quantitative morphological cell phenotyping.Computational and structural biotechnology journal · 2024Review
- Rational selection of morphological phenotypic traits to extract essential similarities in chemical perturbation in the ergosterol pathway.Scientific reports · 2024Article
- Application of unimodal probability distribution models for morphological phenotyping of budding yeast.FEMS yeast research · 2024Article
- Targeted Mutations Produce Divergent Characteristics in Pedigreed Sake Yeast Strains.Microorganisms · 2023Article
- Assignment of unimodal probability distribution models for quantitative morphological phenotyping.BMC biology · 2022Article
- High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds.NPJ systems biology and applications · 2022Article
- Defining Functions of Mannoproteins inJournal of fungi (Basel, Switzerland) · 2021Article
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- A practical guide to intelligent image-activated cell sorting.Nature protocols · 2019Article
- Cucurbitacin B Exerts Antiaging Effects in Yeast by Regulating Autophagy and Oxidative Stress.Oxidative medicine and cellular longevity · 2019Article
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Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe size of the phenotypic effect of a gene has been thoroughly investigated in terms of fitness and specific morphological traits in the budding yeast Saccharomyces cerevisiae, but little is known about gross morphological abnormalities.
resultsWe identified 1126 holistic morphological effectors that cause severe gross morphological abnormality when deleted, and 2241 specific morphological effectors with weak holistic effects but distinctive effects on yeast morphology. Holistic effectors fell into many gene function categories and acted as network hubs, affecting a large number of morphological traits, interacting with a large number of genes, and facilitating high protein expression. Holistic morphological abnormality was useful for estimating the importance of a gene to morphology. The contribution of gene importance to fitness and morphology could be used to efficiently classify genes into functional groups.
conclusionHolistic morphological abnormality can be used as a reproducible and reliable gene feature for high-dimensional morphological phenotyping. It can be used in many functional genomic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.