Evidence map›Paper›PMID 29459675›Full record

ArticleScientific reports2018

c-Jun N-terminal kinase 1 defective CD4+CD25+FoxP3+ cells prolong islet allograft survival in diabetic mice.

Deepak Tripathi, Satyanarayana S Cheekatla, Padmaja Paidipally, Rajesh Kumar Radhakrishnan, Elwyn Welch, Ramya Sivangala Thandi, Amy R Tvinnereim, Ramakrishna Vankayalapati

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Improving the Efficacy of Regulatory T Cell Therapy.Clinical reviews in allergy & immunology · 2022
    Review
  5. Article
  6. Article
  7. Next-generation regulatory T cell therapy.Nature reviews. Drug discovery · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Deepak TripathiDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas, 75708, USA. Deepak.Tripathi@uthct.edu.
Satyanarayana S CheekatlaDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas, 75708, USA.
Padmaja PaidipallyDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas, 75708, USA.
Rajesh Kumar RadhakrishnanDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas, 75708, USA.
Elwyn WelchDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas, 75708, USA.
Ramya Sivangala ThandiDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas, 75708, USA.
Amy R TvinnereimDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas, 75708, USA.
Ramakrishna VankayalapatiDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas, 75708, USA.
The University of Texas Health Science Center at Tyler · USGITAM University · IN

Funding

Treg suppression of islet allograft rejectionR01AI088201 · NIAID · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI VANKAYALAPATI, RAMAKRISHNA · 2010 to 2014
$1.4M
NIAID NIH HHS R01 AI088201
6 · The paper itself

Abstract

CD4+CD25+FoxP3+ cells (Tregs) inhibit inflammatory immune responses to allografts. Here, we found that co-transplantation of allogeneic pancreatic islets with Tregs that are defective in c-Jun N-terminal kinase 1 (JNK1) signaling prolongs islet allograft survival in the liver parenchyma of chemically induced diabetic mice (CDM). Adoptively transferred JNK1

Indexed as

AllograftsAnimalsAntigens, CDCD4-Positive T-LymphocytesDiabetes Mellitus, ExperimentalForkhead Transcription FactorsGene Expression RegulationGraft SurvivalHumansInterleukin-17Interleukin-21Interleukin-2 Receptor alpha SubunitInterleukinsLymphocyte Activation Gene 3 ProteinMiceMice, Inbred NODAntigens, CDForkhead Transcription FactorsFoxp3 protein, mouseInterleukin-17Interleukin-21Interleukin-2 Receptor alpha SubunitInterleukinsLymphocyte Activation Gene 3 ProteinMitogen-Activated Protein Kinase 8

Identifiers

PMID29459675
PMCPMC5818514
OpenAlexW2807442724

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.